基底节区血管周围间隙扩大与非血管性认知障碍的关系

发布时间：2018-05-30 21:53

  本文选题：认知障碍 + 血管周围间隙扩大　； 参考：《临床神经病学杂志》2015年01期

【摘要】：目的探讨基底节区血管周围间隙扩大(EPVS)与非血管性认知障碍的关系。方法对63例Alzheimer's病(AD)患者(AD组)、59例非血管性轻度认知障碍(MCI)患者(MCI组)及60名健康对照者(正常对照组)行头颅MRI检查。比较各组及不同年龄段基底节区EPVS。结果 AD组及MCI组EPVS评分显著高于正常对照组(均P0.01)。AD组EPVS评分显著高于MCI组(P0.01)。与正常对照组比较,AD组及MCI组分级构成差异有统计学意义(均P0.01)。AD组与MCI组分级构成的差别无统计学意义。60岁时,AD组EPVS评分显著高于MCI组及正常对照组(均P0.01),AD组与正常对照组分级构成差异有统计学意义(P0.05)。60~80岁时,三组间EPVS评分两两比较差异有统计学意义(均P0.01),对照组的分级构成与AD组和MCI组的差异有统计学意义(均P0.01);80岁时,三组间EPVS评分及分级构成差异无统计学意义。结论在≤80岁的人群中,基底节区EPVS与非血管性认知障碍有关。
[Abstract]:Objective to investigate the relationship between the enlargement of perivascular space in basal ganglia and non vascular cognitive impairment. Methods brain MRI was performed in 63 patients with Alzheimer's 's disease and 59 patients with non-vascular mild cognitive impairment (MCI) and 60 healthy controls (normal control group). The EPVS of basal ganglia in each group and in different age groups were compared. Results the EPVS score in AD group and MCI group was significantly higher than that in normal control group (all the EPVS scores in P0.01).AD group were significantly higher than that in MCI group (P 0.01). Compared with the normal control group, the grade composition of AD group and MCI group were significantly different (there was no significant difference between P0.01).AD group and MCI group. The EPVS score of AD group at 60 years old was significantly higher than that of MCI group and normal control group (P0.01). The grade composition of normal control group was significantly different from that of control group at the age of 80 years. There were significant differences in EPVS scores among the three groups (all P 0.01), and there was significant difference between the control group and the AD group and the MCI group (all P 0.01 or 80 years old). There was no significant difference in the EPVS score and the grading composition among the three groups at the age of 80 years. Conclusion EPVS in basal ganglia is associated with non vascular cognitive impairment in people aged 鈮，

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