迷迭香复合精油治疗脑卒中后抑郁焦虑共病的临床观察

发布时间：2018-05-31 13:06

本文选题：脑卒中后抑郁焦虑共病(PSCAD) + 抑郁症　；参考：《安徽医科大学》2014年硕士论文

【摘要】：目的本实验采用迷迭香复合精油吸嗅治疗脑卒中后抑郁焦虑共病（PSCAD）患者，通过测评患者的HAMD及HAMA评分，观察治疗前、后患者抑郁及焦虑症状改善情况，初步探讨迷迭香复合精油治疗抑郁和焦虑的临床应用价值。方法 1.分组：遵循循证医学，选取2012年2月至2013年5月在安徽医科大学第一附属医院康复医学科收治的脑卒中患者60例，采用随机数字表法将上述患者分为治疗组和对照组，每组各30例，2组患者的性别、文化程度、年龄、病程、卒中部位、卒中性质及HAMD、HAMA评分等方面差异均无显著性(P0.05)。 2.治疗方法：2组患者均予以脑卒中常规康复治疗。（1）治疗组：取迷迭香复合精油0.4ml，用20ml常温纯净水稀释后放入扩香仪托盘中，放在50cm×40cm×30cm的密闭塑料盒中，，利用灯泡加热，使用鼻导管吸入鼻孔内，吸入时间为30min，每晚一次，治疗时间为持续8周。（2）对照组：口服舍曲林，每晚一次，每次50mg，治疗时间为持续8周。 3.疗效评价：分别于治疗前、治疗2W、治疗4W、治疗6W及治疗8W后的五个时间点，采用HAMD量表和HAMA量表对2组患者进行疗效评定,上述测评均由相同2名经专业培训的康复医师完成。在治疗过程中同时对2组患者进行血常规、尿常规、肝肾功能及心电图检查，并密切观察2组患者不良反应发生情况。结果 1．2组患者的HAMD评分比较结果：治疗组和对照组HAMD评分在治疗前、治疗2W、治疗4W、治疗6W及治疗8W后五个时间点的其间差异均有统计学意义（F=623.66，P=0.000），但2组患者HAMD评分在不同时间点组间差异均无统计学意义（P0.05）；2组患者治疗前与治疗8周末HAMD评分比较均有差异性（P0．01），治疗后HAMD评分均呈下降趋势，提示治疗组HAMD评分与对照组相当。 2.2组患者的HAMA评分比较结果：治疗组和对照组HAMA评分在治疗前、治疗2W、治疗4W、治疗6W及治疗8W后五个时间点的其间差异均有统计学意义（F=549.68，P=0.000），但2组患者HAMA评分在不同时间点组间差异均无统计学意义（P0.05）；2组患者治疗前与治疗8W末HAMA评分比较均有差异性（P0．01），治疗后HAMA评分均呈下降趋势，提示治疗组HAMA评分与对照组相当。 3.不良反应：治疗组与对照组治疗8W后均无l例出现不良反应，血常规、尿常规、肝肾功能及心电图检查均未见明显异常改变。结论 1.迷迭香复合精油吸嗅治疗脑卒中后抑郁焦虑共病的临床疗效确切，可以显著改善患者的抑郁及焦虑症状。 2.迷迭香复合精油吸嗅治疗抑郁和焦虑症状的临床疗效与舍曲林相当。 3.迷迭香复合精油吸嗅无明显不良反应，安全性高。
[Abstract]:Purpose In this experiment, rosemary combined with essential oil sniffing was used to treat patients with post-stroke depression and anxiety syndromes. The patients' HAMD and HAMA scores were evaluated to observe the improvement of depression and anxiety symptoms before and after treatment. To explore the clinical application value of Rosemary compound essential oil in the treatment of depression and anxiety. Method 1. Group: according to evidence-based medicine, 60 stroke patients treated in the Department of Rehabilitation Medicine, first affiliated Hospital of Anhui Medical University from February 2012 to May 2013, were randomly divided into treatment group and control group. There was no significant difference in sex, education level, age, course of disease, location of stroke, nature of stroke and Hamd Hama score between each group (30 cases) and two groups (P 0.05). 2. Methods: two groups of patients were treated with routine rehabilitation of stroke. 1) treatment group: Rosemary compound essential oil 0.4ml, diluted with 20ml pure water at room temperature, placed in the tray of diffuser, placed in the sealed plastic box of 50cm 脳 40cm 脳 30cm, heated by light bulb, inhaled into nostril with nasal catheter for 30 mins, once a night, The treatment lasted for 8 weeks. Control group: oral sertraline, once a night, 50 mg each time, the treatment lasted for 8 weeks. 3. Evaluation of curative effect: at the five time points before treatment, treatment of 2W, treatment of 4W, treatment of 6W and treatment of 8W, HAMD and HAMA were used to evaluate the curative effect of the two groups. The above evaluation was completed by the same two rehabilitators who were trained professionally. The blood routine, urine routine, liver and kidney function and electrocardiogram were examined in both groups during the course of treatment, and the adverse reactions of the two groups were observed closely. Result 1. 2 comparison of HAMD scores of patients in the treatment group and the control group: before treatment, the HAMD score of the treatment group and the control group, There were statistically significant differences among the five time points after treatment 2 W, 4 W, 6 W and 8 W, respectively. However, there was no significant difference in HAMD scores between the two groups before and after 8 weeks of treatment. The HAMD scores were significantly different (P 0.01), and the HAMD scores decreased after treatment. It suggested that the HAMD score of the treatment group was equal to that of the control group. 2.2 comparison of HAMA scores of patients in the treatment group and the control group: before treatment, the HAMA score in the treatment group and the control group, There were statistically significant differences among the five time points after treatment 2 W, 4 W, 6 W and 8 W, respectively. However, there was no significant difference in HAMA scores between the two groups at different time points. There was no significant difference between the two groups before treatment and at the end of 8 weeks of treatment, but there was no significant difference in HAMA scores between the two groups before treatment and at the end of 8 weeks of treatment. There were significant differences in the scores between the two groups (P 0.01), and the HAMA scores showed a downward trend after treatment. It suggested that the HAMA score of the treatment group was equal to that of the control group. 3. Adverse reactions: there were no adverse reactions in both the treatment group and the control group after 8 weeks treatment. There were no obvious abnormal changes in blood routine, urine routine, liver and kidney function and electrocardiogram. Conclusion 1. Rosemary combined with essential oil sniffing is effective in the treatment of post-stroke depression and anxiety syndromes, and can significantly improve the symptoms of depression and anxiety. 2. Rosemary combined with essential oil sniffing is as effective as sertraline in the treatment of depression and anxiety. 3. Rosemary compound essential oil sniffing no obvious adverse reaction, high safety.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3;R749

【参考文献】