伴轻度认知障碍的正常眼压性青光眼多导睡眠图分析

发布时间：2018-05-31 14:28

本文选题：正常眼压性青光眼 + 轻度认知障碍　；参考：《中国神经精神疾病杂志》2015年09期

【摘要】：目的探讨伴轻度认知障碍(mild cognitive impairment,MCI)的正常眼压性青光眼(normal tension glaucoma,NTG)患者多导睡眠图的特点。方法本研究对35例经北京大学第三医院眼科确诊为NTG的患者,均进行神经心理量表测评、匹兹堡睡眠质量指数(Pittsburgh slrrp quality index,PSQI)和多导睡眠图(polysomnography,PSG)检查,其中伴MCI者16例(伴MCI组),不伴MCI者19例(不伴MCI组)。结果 PSQI显示伴MCI组中有睡眠障碍者占43.8%(7/16例),其PSQI总分高于不伴MCI组,差异有统计学意义(P0.05)。不伴MCI组患者睡眠效率正常,且优于伴MCI组,差异有统计学意义(P0.05)。PSG显示伴MCI组患者87.5%(14/16)存在PSG睡眠结构紊乱。伴MCI组较不伴MCI组NREM期N3期睡眠时间明显缩短,差异有统计学意义(P0.05)。结论伴MCI组NTG患者更易出现睡眠障碍,睡眠结构紊乱、尤其是NREM期N3期睡眠时间的缩短与NTG患者认知功能下降有关。
[Abstract]:Objective to investigate the characteristics of polysomnography in normal tension glaucoma (NTG) patients with mild cognitive impairment (MCI). Methods 35 patients with NTG diagnosed by ophthalmology of Peking University third Hospital were assessed with the Pittsburgh Sleep quality Index (PSQI) and polysomnography (PSG). There were 16 cases with MCI (with MCI group and 19 cases without MCI group). Results PSQI showed that there were 16 cases with sleep disorder in 43.8% of the patients with MCI. The total score of PSQI was higher than that of the group without MCI, and the difference was statistically significant (P 0.05). The sleep efficiency of the patients without MCI was normal and better than that of the patients with MCI. The difference was statistically significant (P 0.05) .PSG showed that there was a disorder of PSG sleep structure in patients with MCI (87.5% 14 / 16). The sleep time of NREM stage N3 in MCI group was significantly shorter than that in MCI group, and the difference was statistically significant (P 0.05). Conclusion NTG patients with MCI are more likely to have sleep disorders, sleep structure disorder, especially the shortening of sleep time in NREM stage N3, is related to the decrease of cognitive function in NTG patients.
【作者单位】：北京大学第三医院神经内科;河北省沧州市中心医院神经内三科;北京大学第三医院眼科;北京大学第三医院耳鼻喉科;
【分类号】：R775;R749.1

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