中国重庆地区老年人群MCI与代谢因素的相关性分析

发布时间：2018-06-03 04:49

本文选题：代谢因素 + 轻度认知功能障碍　；参考：《重庆医科大学》2013年硕士论文

【摘要】：目的：探讨中国重庆地区老年人中与MCI有关的代谢相关危险因素。方法：本研究采用蒙特利尔量表北京版(MoCA-BJ)作为评估认知功能的工具。本研究包括社区MCI组（n=70）和社区NC组（n=187），住院MCI组（n=83）和住院NC组（n=145）。收集资料包括年龄，性别，教育背景，是否赋闲，，吸烟史，饮酒史，疾病谱，家族史，体重指数（BMI）,腰臀比（WHR）等基本情况，以及糖化血红蛋白（HbA1c）,空腹血糖(FBG),餐后2小时血糖(2hPBG),尿酸(UA),肌酐(Cre),总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),高敏C反应蛋白(HsCRP)等生化指标。结果：蒙特利尔北京版评分与教育背景正相关，与年龄和性别负相关。住院患者显示MCI与冠心病（CHD）的发病率、HbA1c有关，与慢性阻塞性肺部疾病（COPD）、短暂性脑缺血发作（TIA）、2型糖尿病（T2DM）的发病率，痴呆家族史，吸烟史，是否赋闲，BMI, WHR, FBG,2hPBG, TG, TC, HDL-C, TC/HDL-C, LDL-C, UA, Cre, HsCRP无关。在社区人群中，MCI与T2DM的发病率，吸二手烟，FBG,2hPBG, HbA1c, TC,HDL-C有关，与CHD、COPD、TIA、T2DM的发病率，痴呆家族史，是否赋闲，BMI, WHR, TG, TC/HDL-C, LDL-C, UA, Cre, HsCRP无关。结论：本研究结果显示糖尿病史，血糖水平，总胆固醇水平为老年MCI人群可能的危险因素。体重指数，腰臀比，尿酸，肌酐，甘油三酯，低密度脂蛋白胆固醇，高敏C反应蛋白与MCI无关。
[Abstract]:Objective: To investigate the metabolic risk factors associated with MCI in the elderly in Chongqing, China.
Methods: This study used the Montreal scale Beijing Version (MoCA-BJ) as a tool to evaluate cognitive function. This study included community MCI (n=70) and community NC group (n=187), group MCI (n=83) and hospitalized NC (n=145). The data included age, sex, educational background, leisure, smoking history, drinking history, disease spectrum, family history, body mass index. (BMI) basic conditions such as waist to hip ratio (WHR), as well as glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2 hours postprandial blood glucose (2hPBG), uric acid (UA), creatinine (Cre), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and high sensitive C reactive protein.
Results: the Beijing score in Montreal was positively related to educational background and negative correlation with age and sex. Inpatient patients showed the incidence of MCI and coronary heart disease (CHD), HbA1c related to chronic obstructive pulmonary disease (COPD), transient ischemic attack (TIA), the incidence of type 2 diabetes (T2DM), the history of dementia family, smoking history, leisure, BMI, WHR, FBG, 2hPBG, TG, TC, HDL-C, TC/HDL-C, LDL-C, UA, Cre, HsCRP independent.
Conclusion: the results of this study showed that the history of diabetes, blood glucose level, and total cholesterol levels were possible risk factors for the elderly MCI population. The body mass index, waist to hip ratio, uric acid, creatinine, triglyceride, low density lipoprotein cholesterol, and high sensitive C reactive protein were not related to MCI.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.2

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