阿尔茨海默病患者脑血氧信号复杂度的多尺度熵分析

发布时间：2018-06-03 20:01

本文选题：功能性近红外成像 + 阿尔茨海默病　；参考：《医学研究生学报》2016年12期

【摘要】：目的目前对于阿尔茨海默病(Alzheimer's disease,AD)患者脑内血氧信号的非线性特性研究较少。文中旨在探讨通过多尺度熵(multiscale entropy,MSE)方法表述AD患者脑内动态血氧信号的复杂度特征,并评估其对于阐释AD病理生理机制的作用。方法收集2010年12月至2015年9月于首都医科大学宣武医院神经内科记忆门诊就诊的AD患者24例,为AD组;招募来自社区的性别、年龄及受教育程度与AD组相匹配的健康老年人31名为健康对照组。采集31名健康对照者以及24例AD患者的静息态功能性近红外成像数据,分析比较各组血氧信号的MSE特征,并分析其与认知功能的关系。结果 AD组的MSE全脑均值小于健康对照组[(6.23±0.32)vs(7.13±0.41)]。在各个功能网络内,AD患者MSE值较健康对照组在默认网络(6.069 vs 7.222),额顶网络(6.038 vs 6.972),腹侧注意网络(6.238 vs 7.325)、背侧注意网络(6.143 vs 7.035)及视觉网络(5.981 vs 6.919)中均显著降低(P0.05)。MSE值与整体认知功能在腹侧注意网络中存在边缘显著的正相关(r=0.410,P=0.065)。结论基于MSE的分析方法有潜力成为表述及阐释AD患者异常皮层血氧信号复杂度的新手段。
[Abstract]:Objective to study the nonlinear characteristics of cerebral blood oxygen signal in Alzheimer's disease (AD) patients. The purpose of this paper is to study the complexity characteristics of dynamic blood oxygen signal in brain of AD patients by multiscale entropy scale multiscale (MSE) method and to evaluate its role in explaining the pathophysiological mechanism of AD. Methods from December 2010 to September 2015, 24 patients with AD were enrolled in the Department of Neurology, Department of Neurology, Xuanwu Hospital, Capital Medical University. The age and education level of 31 healthy elderly matched with AD group were healthy control group. The resting functional near infrared imaging data of 31 healthy controls and 24 AD patients were collected to analyze and compare the MSE characteristics of blood oxygen signals in each group and their relationship with cognitive function. Results the mean value of MSE in AD group was lower than that in healthy control group [6.23 卤0.32)vs(7.13 卤0.41]. The MSE values of AD patients in each functional network were significantly lower than those of the healthy control group in the default network 6.069 vs 7.222n, the frontal-top network 6.038 vs 6.972, the ventral attention network 6.238 vs 7.325m, the dorsal attention network 6.143 vs 7.035) and the visual network 5.981 vs 6.919). In the ventral attention network, there was a significant positive correlation between physical and cognitive function in the ventral attention network. Conclusion the analysis method based on MSE has the potential to be a new method to describe and explain the complexity of abnormal cortical oxygen signal in AD patients.
【作者单位】：首都医科大学宣武医院康复医学科;首都医科大学宣武医院神经内科;吉林油田总医院神经内科;北京师范大学认知神经科学与学习国家重点实验室&IDG/麦戈文脑科学研究院;
【基金】：国家自然科学基金(31371007,81430037,61633018) 北京市自然科学基金重点项目(7161009) 北京市科委首都市民健康培育项目(Z131100006813022,Z161100002616020) 首都医科大学基础临床合作项目(16JL-L08) 顺义区卫计委资助(SY2016001)
【分类号】：R749.16

【相似文献】