血管性痴呆与脑脊液生长抑素及事件相关电位的相关性

发布时间：2018-06-04 18:23

本文选题：血管性痴呆 + 脑梗死　；参考：《中国老年学杂志》2016年15期

【摘要】：目的探讨血管性痴呆(VD)患者脑脊液中生长抑素(SS)含量及事件相关电位P300潜伏期(P300PL)的变化和意义,并探讨脑脊液(CSF)中SS含量与痴呆的发病部位及痴呆程度的关系。方法选择VD患者50例为VD组,同期选择无认知障碍的脑梗死患者30例为对照组,应用简易精神状态量表(MMSE)、P300PL评定患者的认知功能,采用放射免疫法检测患者CSF中SS含量。结果 1VD组患者CSF中SS含量显著低于对照组(P0.05),P300PL显著延长(P0.05);2VD组患者CSF中SS含量与MMSE量表评分呈正相关(r=0.514,P0.01),与P300PL呈负相关(r=-0.892,P0.01);3发生于额叶皮层、海马、颞叶皮层、丘脑、纹状体等部位的脑梗死患者脑脊液SS含量明显降低(P0.05)。结论 1VD患者CSF中SS含量明显降低,其降低程度与认知功能损害程度相一致,脑内SS含量降低可能是脑梗死患者出现痴呆的原因之一。2CSF中SS含量降低与VD患者脑梗死的发病部位有一定相关性。3VD患者P300PL显著延长可作为评定VD客观的重要指标之一。
[Abstract]:Objective to investigate the changes and significance of somatostatin (SS) in cerebrospinal fluid (CSF) and event-related potential (P300 latencies) in patients with vascular dementia (VD), and to explore the relationship between SS content in CSF and the location of dementia and the degree of dementia. Methods 50 patients with VD were selected as VD group and 30 patients with cerebral infarction without cognitive impairment as control group. The cognitive function was assessed by MMSE P300PL and SS content in CSF was measured by radioimmunoassay. Results the SS content in CSF in 1VD group was significantly lower than that in control group P0.05 and P300PL. The SS content in CSF was positively correlated with MMSE scale score in patients with P0.05 and 2VD, and negatively correlated with P300PL in frontal cortex, hippocampus, temporal cortex, thalamus. SS content in cerebrospinal fluid (CSF) of patients with cerebral infarction such as striatum decreased significantly (P 0.05). Conclusion the content of SS in CSF of patients with 1VD was significantly lower than that in patients with 1VD, and the degree of decrease was consistent with the degree of cognitive impairment. The decrease of SS content in brain may be one of the causes of dementia in patients with cerebral infarction. The decrease of SS content in CSF has certain correlation with the location of cerebral infarction in VD patients. 3The prolongation of P300PL in patients with VD can be regarded as one of the important indexes to evaluate VD objectively.
【作者单位】：宁夏回族自治区人民医院神经内科;濮阳市人民医院神经内一科;
【基金】：宁夏自然科学基金资助项目(NZ14173)
【分类号】：R749.13

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