银杏叶片提取物EGB761联合高压氧治疗阿尔茨海默病的疗效分析

发布时间：2018-06-04 16:37

本文选题：阿尔茨海默病 + 高压氧　；参考：《东南大学学报(医学版)》2017年02期

【摘要】：目的:研究应用高压氧(HBO)联合银杏叶片提取物(EGB761)治疗阿尔茨海默病(AD)的临床疗效及机制。方法:纳入2013年12月至2016年6月南京脑科医院初诊断AD患者共120例,按随机数字法将120例患者随机分为对照组、HBO治疗组、EGB761治疗组、HBO联合EGB761治疗组。所有患者治疗前后进行MMSE、ADL、ADAS-Cog量表评估,并抽血检测TGF-β_1、IL-1β、SOD、MDA、GSH-PX水平。结果:HBO治疗组及EGB761治疗组量表评估较基线时评分均有明显的改善;此外,联合使用HBO及EGB761较单用HBO或EGB761治疗改善更明显;HBO组、EGB761组和HBO+EGB76l组的血清SOD活性、GSH-PX、TGF-β_1的含量水平均提高,MDA及IL-1β水平降低,且HBO联合EGB761治疗组血清中相关因子水平的改变更为显著。结论:HBO联合EGB761对改善AD患者认知能力、日常生活活动能力效果确切,可能与其抑制氧化自由基及炎症因子的过度损伤有关。
[Abstract]:Objective: to study the clinical effect and mechanism of hyperbaric oxygen (HBO) combined with Ginkgo biloba leaf extract (EGB761) in the treatment of Alzheimer's disease (AD). Methods: from December 2013 to June 2016, 120 patients with AD diagnosed in Nanjing brain Hospital were randomly divided into two groups: control group (control group) treated with EGB761 plus EGB761. All the patients were assessed with ADAS-Cog scale before and after treatment, and the level of GSH-PX was measured by TGF- 尾 1, IL-1 尾 and SODDA-MDA-PX. Results the scores of the two groups were significantly improved compared with the baseline, in addition, there was no significant difference between the two groups. The serum SOD activity and the level of GSH-PXTGF- 尾 1 in HBO group were significantly improved compared with that of HBO or EGB761 alone. The level of GSH-PXX TGF- 尾 1 was increased and the level of related factors in serum of HBO combined with EGB761 group was significantly increased. Conclusion the effect of EGB761 combined with EGB761 on the cognitive ability and ADL of AD patients is effective, which may be related to the inhibition of oxidative free radicals and excessive injury of inflammatory factors.
【作者单位】：南京医科大学附属脑科医院老年医学科;东南大学附属中大医院高压氧科;
【基金】：南京市医学科技发展重点项目(ZKX13034)
【分类号】：R749.16

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