心房颤动与非卒中性认知功能障碍关系的病例对照研究

发布时间：2018-06-04 12:25

本文选题：心房颤动 + 认知功能障碍　；参考：《兰州大学》2017年硕士论文

【摘要】：目的:心房颤动是老年人中最为常见的心律失常,随着人口老龄化不断加速,高血压、糖尿病、冠心病等心血管相关疾病的患病率不断增加,房颤的发病率在全球范围内呈升高趋势。许多国外研究表明,房颤可以导致非卒中性认知功能障碍并可加速认知功能进一步恶化,认知功能障碍导致个人生活质量的下降、家庭和社会的经济负担加重,成为人们逐渐关注的焦点。因此本研究通过对房颤及非房颤患者进行一般资料的统计及MMSE、MoCA量表认知功能评价,探讨房颤与非卒中性认知功能障碍的相关性。方法:本研究以2015年4月-2016年10月就诊于兰州大学第二医院心内科的非卒中房颤患者共99名设为病例组,以房颤患者性别、年龄、受教育程度为匹配因素纳入99名非房颤患者作为对照组,记录患者一般资料、统计患者辅助检查结果,通过MMSE及MoCA量表对两组患者进行认知功能评价,比较两组患者认知功能障碍的患病情况。结果:1)通过MMSE量表评估,病例组患者存在认知功能障碍30人(30.3%),对照组患者存在认知功能障碍者18人(18.2%),两组通过配对卡方检验示,P0.001,两组差异有统计学意义。2)通过MoCA量表评估,病例组患者中存在认知障碍者90人(90.9%),对照组患者中存在认知障碍者73人(73.7%),P0.001,两组差异有统计学意义。两种量表检查均提示病例组中认知功能障碍的患病率较高。结论房颤是导致非卒中性认知功能障碍的独立危险因素。
[Abstract]:Objective: atrial fibrillation is the most common arrhythmia in the elderly, and the prevalence of cardiovascular diseases such as hypertension, diabetes, coronary heart disease and so on increases with the aging of the population. The incidence of atrial fibrillation is increasing worldwide. Many foreign studies have shown that atrial fibrillation can lead to non-stroke neutral cognitive dysfunction and accelerate the further deterioration of cognitive function, cognitive dysfunction leads to a decline in personal quality of life, family and social economic burden. Become the focus that people pay attention to gradually. Therefore, this study investigated the correlation between atrial fibrillation and non-stroke neutral cognitive dysfunction by statistical analysis of general data and evaluation of cognitive function of MMSE MoCA scale in patients with atrial fibrillation and non-atrial fibrillation. Methods: from April 2015 to October 2016, 99 patients with non-apoplectic atrial fibrillation in Department of Cardiology, second Hospital of Lanzhou University were selected as the case group. The educational level was matched by 99 non-atrial fibrillation patients as the control group. The general data of the patients were recorded and the results of auxiliary examination were counted. The cognitive function of the two groups was evaluated by MMSE and MoCA scale. To compare the prevalence of cognitive dysfunction between the two groups. Results according to the MMSE scale, 30 patients with cognitive dysfunction in the case group and 18 patients with cognitive dysfunction in the control group were assessed by MoCA scale. The matched chi-square test showed P 0.001. The difference between the two groups was statistically significant. 90 patients with cognitive impairment in the case group and 73 patients with cognitive impairment in the control group had cognitive impairment (P 0.001). The difference between the two groups was statistically significant. The prevalence of cognitive impairment was higher in the two scales. Conclusion Atrial fibrillation is an independent risk factor for non-apoplectic cognitive impairment.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.75;R749.1

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