首发未经治疗抑郁症患者BDNF基因多态性和脑结构之间的关系

发布时间：2018-06-05 06:33

本文选题：BDNF基因 + 抑郁症　；参考：《昆明医科大学》2017年硕士论文

【摘要】：目的:研究首发未经治疗抑郁症患者和健康对照的BDNF Va166Met基因型和全脑灰质体积之间的关系。方法:本研究纳入符合DSM-IV诊断标准的首发未经治疗抑郁障碍患者组41名以及性别、年龄相匹配的健康对照组44名,行头部3D结构磁共振扫描。根据BDNF基因分型结果将抑郁症患者组和健康对照组进一步分为,抑郁症Met等位基因携带者组,抑郁症Va1/Val纯合子组,健康对照Met等位基因携带者组,健康对照Val纯合子组。所得到的结构磁共振数据采用基于Matlab 2012软件平台上的VBM 8软件进行自动化分割处理,分别分割处理抑郁症患者组和健康对照组的脑灰质体积。全脑范围,采用2x2 ANOVA全因子模型分析诊断和基因型对全脑灰质体积影响分别的主效应以及交互效应。结果:1.抑郁症患者组和健康对照组rs6265的等位基因频率(p=0. 992833)和基因型分布(p=0.956498)两组之间未显示出统计学差异(P0. 05)。2.抑郁症患者组与健康对照组相比,左侧楔前叶增大(p0. 05)。3.2x2 ANOVA全因子模型分析结果显示(p0.05) : (a)BDNF基因型对脑灰质体积影响主效应:左侧小脑、左侧梭状回减小,右侧顶上回增大。(b)诊断对脑灰质体积影响主效应:左侧楔前叶增大。(c)BDNF基因与诊断对脑灰质体积影响的交互效应:左侧前扣带回减小。在Val纯合子组中,抑郁症患者组与健康对照组相比,发现左侧海马旁回、右侧前扣带回灰质体积减小。在Met等位基因组中,抑郁症患者组与健康对照组相比,发现左侧额中回、右侧额中回灰质体积增大。结论:1.与健康对照组相比,抑郁症患者组左侧楔前叶灰质体积增大。2.本研究表明,rs6265位点的遗传变异可能导致左侧小脑、左侧海马旁回灰质体积减小和右侧顶上回灰质体积增大。3.左侧前扣带回灰质体积减小是BDNF和抑郁症共同作用的结果,这提示BDNF Va166Met多态性可能在抑郁症早期发病机制中发挥重要作用。
[Abstract]:Aim: to study the relationship between BDNF Va166Met genotype and global gray matter volume in untreated depression patients and healthy controls. Methods: 41 patients with untreated depressive disorder and 44 healthy controls matched with sex and age were enrolled in this study. According to the results of BDNF genotyping, the patients with depression and the healthy control group were further divided into Met allele carrier group, Va1/Val homozygous group, Met allele carrier group and Val homozygote group. The obtained structural magnetic resonance data were automatically segmented by VBM 8 software based on Matlab 2012 software platform. The gray matter volumes in depression group and healthy control group were segmented respectively. In the whole brain, the main effect and interaction effect of diagnosis and genotype on the whole brain gray matter volume were analyzed by 2x2 ANOVA full-factor model. The result is 1: 1. The allele frequency of rs6265 in depression group and healthy control group was 0. 0. There was no statistical difference between the two groups (P 0. 0) and genotype distribution (P 0. 956 49 8). 05. 2. Compared with the healthy control group, the patients with depression increased the left anterior cuneate lobe (P 0. 0). The results of 05).3.2x2 ANOVA full-factor model analysis showed that: the main effect of BDNF genotype on the gray matter volume was: the left cerebellum, the left fusiform gyrus decreased, and the left fusiform gyrus decreased in the left cerebellum. The main effects of right superior gyrus enlargement on gray matter volume were as follows: the interaction effect of BDNF gene of left anterior wedge enlargement and diagnosis on gray matter volume: the decrease of left anterior cingulate gyrus. In the Val homozygous group, the volume of gray matter in the right anterior cingulate gyrus was decreased in the depression group compared with the control group. In the Met allele, the left middle frontal gyrus and the right middle frontal gyrus were found to be larger in the depression group than in the healthy control group. Conclusion 1. Compared with the healthy control group, the gray matter volume of the left anterior cuneate lobe in the depression group increased by. 2. 2. This study suggests that the genetic variation at rs6265 may lead to a decrease in the volume of gray matter in the left cerebellum, a decrease in the volume of gray matter in the left parahippocampal gyrus and an increase in the volume of gray matter in the right superior parietal gyrus. The decrease of gray matter volume in left anterior cingulate gyrus is the result of BDNF and depression, which suggests that BDNF Va166Met polymorphism may play an important role in the early pathogenesis of depression.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.4

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