尿微量蛋白与血管性痴呆的相关性研究

发布时间：2018-06-06 10:49

本文选题：尿微量蛋白 + 血管性痴呆　；参考：《吉林大学》2015年硕士论文

【摘要】：目的：目前，对于血管性痴呆危险因素及其发病机制的研究很多，但是明确的机制尚不十分清楚，大多数研究都是从脑血管病方面进行阐述的。然而，近些年对尿微量蛋白的研究发现，其与公认的血管性痴呆病因涉及的脑血管病及其危险因素密切相关。故本文通过尿微量蛋白(microalbuminuria MA）与血管性痴呆（Vascular Dementia，VD）的相关性研究，探讨VD的可能危险因素,对寻求其有效的预防和治疗措施或许具有十分重要的意义。实验方法：先对36例血管性痴呆患者，38例脑梗塞（Cerebral Infarction,CI）患者，32例正常健康者(Normal Control,NC)进行病例对照分析，再将VD组中的27例多梗死性痴呆（multi-infarct dementia，MID）患者，同CI组及NC组患者进行病例对照分析。运用免疫比浊法检测患者MA值，分析MA与VD的相关性，并对各组观察对象一般临床资料进行分析比较，寻找VD的危险因素。实验结果： 1、在VD组、CI组、NC组三组之间及MID组、CI组、NC组三组之间比较中，性别、年龄、文化程度、高脂血症病史、吸烟史、饮酒史均无显著差异(P0.05)；VD组、CI组、NC组三组及MID组、CI组、NC组三组在MMSE得分上均具有统计学意义(P0.05)；高血压病史、高血脂病史、吸烟史、饮酒史在VD组、CI组、NC组三组及MID组、CI组、NC组三组对比中，均无显著差异(P0.05)。 2、VD组、CI组、NC组三组MA值相比中（先测定尿白蛋白，排除尿白蛋白阳性者），VD组最高，NC组最低，进行统计学分析，VD组与CI组无显著差异(P0.05)，VD组及CI组分别与NC组对比，均具有显著差异(P0.05)，在MID组、CI组、NC组三组MA值相比，MID组最高，NC组最低，进行统计学分析，MID组MA值明显高于其他两组，并具有显著性差异(P0.05)。实验结论： 1.VD患者（包括MID及其他类型VD）MA值稍高于CI患者，，两者比较无统计学意义(P0.05)，VD患者MA值明显高于健康对照者，两者比较有统计学意义(P0.05)，CI患者MA值明显高于健康对照者，两者比较有统计学意义(P0.05)。 2.MID患者MA值明显高于CI患者及健康对照者，且三者比较具有统计学意义(P0.05)，提示MA可能为MID的独立危险因素。
[Abstract]:Objective: At present, there are many studies on the risk factors and pathogenesis of vascular dementia, but the clear mechanism is not very clear, most of the research is from the aspect of cerebrovascular disease. However, recent studies on urinary microproteins have found that they are closely associated with cerebrovascular disease and its risk factors, which are recognized as the etiology of vascular dementia. Therefore, by studying the correlation between microalbuminuria MAand vascular dementia and vascular dementia, the possible risk factors of VD may be of great significance in seeking effective preventive and therapeutic measures. Experimental methods: Thirty-eight patients with cerebral infarction (Cerebral InfarctionCII) and 32 normal controls (normal control NCC) were analyzed in 36 patients with vascular dementia and 27 patients with multi-infractive dementia (MDD) in VD group, same as CI group and NC group. The correlation between MA and VD was analyzed by using immune turbidimetric method, and the general clinical data of each group were analyzed and compared to find out the risk factors of VD. Experimental results: 1. Sex, age, education, history of hyperlipidemia and smoking were compared between the three groups of VD group and MID group. There was no significant difference in the history of alcohol consumption. There was no significant difference in the MMSE scores among the three groups (P 0.05, P 0.05), the history of hypertension, hyperlipidemia and smoking. There was no significant difference in the history of alcohol consumption among the three groups of VD group and MID group, and there was no significant difference between the three groups (P 0.05). (2) the MA values of the three groups in CI group were higher than those in NC group (the urine albumin was measured first, and the highest and lowest group was excluded from the positive group. There was no significant difference between the VD group and the CI group, P0.05D group and CI group were compared with the NC group respectively), there was no significant difference between the VD group and the CI group, and the difference was significant between the VD group and the CI group. There was significant difference (P 0.05) between the three groups in MID group and CI group. The MA value of Mid group was significantly higher than that of the other two groups, and there was a significant difference in MA value of Mid group compared with that of Mid group (P 0.05). The experimental conclusions are as follows: The MA value of 1.VD patients (including MID and other types of VD)MA) was slightly higher than that of CI patients. There was no significant difference between the two groups. The MA values of 1.VD patients were significantly higher than those of healthy controls, and the MA values of patients with 1.VD and other types of VD)MA were significantly higher than those of healthy controls. There was significant difference between the two groups (P 0.05). The MA value in 2.MID patients was significantly higher than that in CI patients and healthy controls, and there was statistical significance among the three groups, suggesting that MA might be an independent risk factor for MID.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R749.13

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