TIP技术联合喜乐宁颗粒治疗肝郁脾虚型轻中度抑郁症的临床疗效观察

发布时间：2018-06-06 14:32

本文选题：低阻抗意念导入疗法(TIP技术) + 喜乐宁颗粒　；参考：《北京中医药大学》2017年硕士论文

【摘要】：目的观察低阻抗意念导入疗法(TIP技术)联合喜乐宁颗粒治疗肝郁脾虚型轻中度抑郁症的临床疗效及安全性,为抑郁症的临床治疗提供新的治疗方法。方法将69例在中国中医科学院广安门医院心理睡眠科就诊的肝郁脾虚型轻中度抑郁症患者随机分为治疗组与对照组,治疗组采用TIP技术联合喜乐宁颗粒治疗,对照组用喜乐宁颗粒进行治疗,观察周期为8周,喜乐宁颗粒每日1剂,TIP技术每周2次治疗,每次40-50分钟。疗效指标:心理指标为汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、贝克抑郁量表(BDI)、中医五态人格量表;安全性指标:肝肾功能、血尿常规、心电图。结果治疗组和对照组病例年龄、性别、文化程度、病程,以及各观察指标基线比较无显著差异,P0.05,具有可比性。经过8周治疗,治疗组总有效率为90%,对照组总有效率为74.20%,治疗组优于对照组,P0.05。1抑郁量表得分比较1.1组间比较通过独立样本t检验,两组HAMD、HAMA、BDI评分在4周开始出现差异,P0.05,差异持续至治疗8周,其中HAMA差异明显,P0.01,治疗组优于对照组。对抑郁症症状的治疗,治疗组更有优势。1.2组内比较通过配对样本t检验,治疗4周、8周后,治疗组HAMD、HAMA、BDI得分较治疗前均有明显差异,P0.01;治疗4周后,对照组HAMD、HAMA、BDI得分较治疗前无明显差异,P0.05,治疗8周后,对照组HAMD、HAMA、BDI得分较治疗前有明显差异,P0.05。两组均有良好效果,且在治疗时间上,治疗组起效更快。2五态人格量表得分比较2.1组间比较通过独立样本t检验,两组五态人格量表少阴、太阴因子评分在治疗8周时出现差异,P0.05。2.2组内比较通过配对样本t检验,治疗8周后,治疗组五态人格量表少阴、太阴因子评分出现明显差异,P0.05;对照组五态人格量表太阴因子评分出现明显差异,P0.05。治疗8周后,两组治疗对抑郁症人格易感性均有影响,治疗组作用更明显。结论1.TIP技术联合喜乐宁颗粒治疗与单纯喜乐宁颗粒治疗均能明显改善肝郁脾虚型轻中度抑郁症患者的抑郁症症状;2.TIP技术联合喜乐宁颗粒治疗起效更快,疗效优于单用喜乐宁颗粒;3.TIP技术联合喜乐宁颗粒治疗对抑郁症中焦虑的改善优于单用喜乐宁颗粒;4.TIP技术联合喜乐宁颗粒通过改善抑郁症患者的临床症状,对五态人格量表中少阴、太阴两个维度产生了一定影响,喜乐宁颗粒通过改善抑郁症的临床症状,对太阴这一维度产生了一定影响;5.TIP技术联合喜乐宁颗粒临床应用无明显副作用,安全性好。
[Abstract]:Objective to observe the clinical efficacy and safety of low impedance ideation therapy (tip) combined with Xilening granule in the treatment of mild and moderate depression with liver depression and spleen deficiency, and to provide a new method for the treatment of depression. Methods 69 patients with mild and moderate depression with liver depression and spleen deficiency were randomly divided into treatment group and control group. The treatment group was treated with TIP combined with Xilening granule. The control group was treated with Xilening granule for 8 weeks, and Xilening granule was treated twice a week for 40 to 50 minutes with 1 dose per day. Outcome indicators: Hamilton Depression scale (Hamd), Hamilton anxiety scale (Hamilton anxiety scale), Beck Depression scale (BDI), TCM Five-state Personality scale (TCM), Safety Index: liver and Kidney function, Blood and urine routine, ECG. Results there was no significant difference between the treatment group and the control group in age, sex, education level, course of disease and baseline of each observation index (P 0.05). After 8 weeks of treatment, the total effective rate of the treatment group was 90 and the total effective rate of the control group was 74.20. The treatment group was superior to the control group in comparing the scores of P0.05.1 depression scale and 1.1 groups. The difference between the two groups began to appear at 4 weeks after treatment (P 0.05), and the difference lasted until 8 weeks. The difference of HAMA was significant (P 0.01), which was better in the treatment group than in the control group. For the treatment of depressive symptoms, the treatment group had more advantages. The comparison between the treatment group and the control group showed that after 4 weeks and 8 weeks of treatment, the BDI score of the treatment group was significantly different from that of the pre-treatment group (P 0.01), and after 4 weeks of treatment, the BDI score of the treatment group was significantly different from that of the control group (P 0.01). There was no significant difference in BDI score between the control group and the control group (P 0.05). After 8 weeks of treatment, the BDI score of the control group was significantly different from that of the control group (P 0.05). Two groups have good effect, and in the treatment time, the treatment group takes effect more quickly .2 five-state personality scale score 2.1 comparison between groups through independent sample t-test, the two groups five-state personality scale less yin, After 8 weeks of treatment, there was a difference in the score of Taiyin factor in P0.05.2.2 group. After 8 weeks of treatment, the five-state personality scale of treatment group was less negative than that of P0.05.2.2 group. There was significant difference in the score of Taiyin factor (P 0.05) and the score of the five state personality scale (P 0.05) in the control group (P < 0.05). After 8 weeks of treatment, both groups had effects on personality susceptibility to depression, especially in the treatment group. Conclusion 1.TIP combined with Xilening granule and Xilonin granule alone can significantly improve the depression symptoms in patients with mild and moderate depression with liver depression and spleen deficiency. 2. The effect of 1.TIP combined with Xilening granule is faster. The curative effect was better than that of Xilening granule alone. 3. The improvement of anxiety in depression was better than that of Xilening granule combined with Xilening granule alone. 4. The clinical symptoms of depression patients were improved by the combination of Xilening granule and Xilening granule. It has a certain effect on the two dimensions of Shaoyin and Taiyin in the Five-state Personality scale. Xilening granule improves the clinical symptoms of depression. It has a certain effect on the dimension of Taiyin. 5. The clinical application of TIP combined with Xilening granule has no obvious side effects and good safety.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.4

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