阿立哌唑与喹硫平合并丙戊酸钠治疗双相障碍抑郁发作的对照研究

发布时间：2018-06-07 18:07

本文选题：双相情感障碍 + 抑郁发作　；参考：《南昌大学》2013年硕士论文

【摘要】：目的：探讨阿立哌唑与喹硫平分别合并丙戊酸钠治疗双相情感障碍抑郁发作的疗效及安全性。方法：将56例符合DSM-IV双相障碍抑郁发作诊断标准的患者随机分为两组。阿立哌唑组28例，予以阿立哌唑合并丙戊酸钠治疗；喹硫平组28例，予以喹硫平合并丙戊酸钠治疗，观察8周。两组分别于治疗前、治疗第1周末、2周末、4周末、6周末、8周末采用汉密尔顿抑郁量表（HAMD-17）、临床大体印象量表（CGI）评定临床疗效。同时采用治疗时出现的症状量表（TESS）进行安全性评估。结果：治疗结束时，两组HAMD-17评分较入组时均显著降低（p0.05）。治疗8周末，临床总体有效率，阿立哌唑组92.9%，喹硫平组96.4%，差异无显著性（p0.05）。两组不良反应发生率均较低，，阿立哌唑组39.3%，喹硫平组32.1%，差异无显著性（p0.05），且程度较轻。结论：阿立哌唑与喹硫平分别合并丙戊酸钠对双相障碍抑郁发作疗效显著，总体疗效相当，且副反应轻，安全性高。
[Abstract]:Objective: to investigate the efficacy and safety of aripiprazole and quintiapine combined with sodium valproate in the treatment of bipolar depression. Methods: 56 patients who met the diagnostic criteria of DSM-IV bipolar disorder were randomly divided into two groups. Aripiprazole group (n = 28) was treated with aripiprazole combined with valproate sodium (n = 28) and quetiapine group (n = 28) with sodium valproate for 8 weeks. Before treatment, the two groups were treated with Hamilton Depression scale (Hamilton Depression scale) and CGI respectively at the 1st weekend, 2nd weekend, 4th weekend and 6th weekend, respectively, and CGI was used to evaluate the clinical efficacy. At the same time, the safety was evaluated by symptom scale (TESS). Results: at the end of treatment, HAMD-17 score of both groups was significantly lower than that of entering group. At the end of 8 weeks, the overall clinical effective rate was 92.9 in aripiprazole group and 96.4 in quintiapine group, with no significant difference (P 0.05). The incidence of adverse reactions was lower in the two groups, 39.3 in aripiprazole group and 32.1in quetiapine group. There was no significant difference between the two groups (p 0.05), and the degree was less than that of aripiprazole group. Conclusion: aripiprazole and quetiapine combined with sodium valproate are effective in the treatment of bipolar disorder depression.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.4

【引证文献】