集体认知行为治疗对广泛性焦虑障碍疗效的随机对照研究

发布时间：2018-06-08 21:41

本文选题：集体认知行为治疗 + 广泛性焦虑障碍　；参考：《中国心理卫生杂志》2017年03期

【摘要】：目的:探索集体认知行为治疗对广泛性焦虑障碍的临床疗效。方法:采用随机对照研究,最终纳入对照组(n=25)与干预组(n=33),两组均服用度洛西汀30~120 mg治疗。干预组除药物外,接受集体认知行为治疗,每周1次,每次90 min,共8次。采用汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、临床评估量表(CGI)在基线、第4周及第8周进行评估。CGI包括病情严重程度(SI)、疗效总评(GI)和疗效指数(EI)3个条目。结果:HAMA评分的重复测量方差分析结果显示,测量时间与分组处理的交互作用有统计学意义(F=4.35,P0.05)。干预组HAMA第4周及第8周的相对于基线的减分值大于对照组,而第4周的痊愈率及有效率高于对照组;在第8周测评点时,干预组HAMD相对于基线的减分值大于对照组,而CGI-SI与CGI-EI评分低于对照组。结论:与单独的药物治疗相比,在药物治疗基础上结合集体认知行为治疗能够早期起效,更为显著地改善广泛性焦虑障碍患者的焦虑症状、抑郁症状和总体病情。
[Abstract]:Objective: to explore the clinical effect of collective cognitive behavior therapy on generalized anxiety disorder. Methods: a randomized controlled study was carried out, and the control group (n = 25) and the intervention group (n = 33) were treated with doloxetine 30 mg / kg. The intervention group received collective cognitive behavior therapy once a week for 90 mins, 8 times a week. Hamilton anxiety scale (Hammara), Hamilton Depression scale (Hamd), Clinical Assessment scale (CGI) were used to evaluate the severity of the disease at baseline, week 4 and week 8, including the severity of the disease, the general efficacy rating (GI) and the efficacy index (EI). Results the results of repeated measurement ANOVA showed that the interaction between measurement time and group treatment was statistically significant (P 0.05). At the 4th and 8th week of Hama in the intervention group, the relative baseline score of the intervention group was higher than that of the control group, but the recovery rate and the effective rate of the intervention group were higher than those of the control group at the 4th and 8th week, and the score of Hamd relative to baseline in the intervention group was higher than that in the control group at the evaluation point of the 8th week. The CGI-SI and CGI-EI scores were lower than those in the control group. Conclusion: compared with drug therapy alone, combined with collective cognitive behavior therapy can improve anxiety symptoms, depression symptoms and general condition of patients with generalized anxiety disorder more significantly.
【作者单位】：北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学);北京大学人民医院;北京大学首钢医院;
【基金】：北京市科学技术委员会首都市民健康培育项目(Z151100003915104)
【分类号】：R749.72

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