BDNF基因功能性多态rs6265与孤独症儿童的相关性研究

发布时间：2018-06-08 23:15

本文选题：脑源性神经营养因子 + 孤独症　；参考：《中国现代医学杂志》2014年16期

【摘要】：目的探讨脑源性神经营养因子(BDNF)基因功能性多态(rs6265)与孤独症儿童(AC)发病的相关性。方法各选取68例AC患儿(AC组)与健康儿童(对照组),用聚合酶链反应-限制性片段长度多态性技术,对BDNF基因rs6265,进行基因型检测,同时利用酶联免疫吸附技术对两组对象的血清BDNF水平进行检测。结果不同病情程度的AC患儿之间的等位基因(χ2=10.6736,P=0.0048)及基因型(χ2=0.9665,P=0.041)的分布差异有显著性;AC患儿的血清BDNF水平高于对照组的,而且AC患儿的AA基因型的患者的血清BDNF水平最低[(25.27±10.42)ng/mL,F=4.4363,P=0.013]。结论 BDNF基因功能性多态rs6265与AC发病相关,并且影响其血清BDNF的表达。
[Abstract]:Objective to investigate the relationship between brain-derived neurotrophic factor (BDNF) gene functional polymorphism rs6265 and autistic children. Methods A total of 68 children with AC and healthy children (control group) were selected to detect BDNF gene rs6265 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). At the same time, the serum BDNF levels were detected by enzyme linked immunosorbent assay (Elisa). Results there were significant differences in the distribution of the alleles (蠂 ~ 2 + 10.6736) and genotype (蠂 ~ 2 ~ 2 ~ (0.9665) P ~ (0. 041) among the AC children with different degree of disease, and the serum BDNF levels in the patients with AA genotype were the lowest [(25.27 卤10.42) ngL / L = 4.4363P0. 013]. Conclusion the functional polymorphic rs6265 of BDNF gene is associated with the pathogenesis of AC and affects the expression of BDNF in serum.
【作者单位】：广西医科大学第一附属医院神经内科;南宁儿童康复中心;
【基金】：广西青年科学基金资助项目(No:桂科青0991036)
【分类号】：R749.94

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