健康人群和慢性精神分裂症病人前脉冲抑制的影响因素

发布时间：2018-06-09 22:22

本文选题：精神分裂症 + 前脉冲抑制　；参考：《首都医科大学学报》2017年02期

【摘要】：目的本研究以健康人群和慢性精神分裂症病人为研究对象,初步探索两者前脉冲抑制(prepulse inhibition,PPI)的影响因素。方法对50名健康成人(健康组)和75名精神分裂症病人(病人组)进行了PPI测试和认知测试。认知测试采用重复神经心理测查系统(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)和Stroop色词测验,并用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评定病人精神症状。结果 1)与健康组相比,病人组PPI抑制率降低(9.4%±29.3%vs 31.7%±26.2%,P0.001);病人组RBANS总分及其5因子分数、Stroop颜色和词语干扰时间[(370.0±48.5),(55.5±15.5),(79.7±15.8),(77.9±12.3),(91.8±12.2),(65.3±18.3),(7.6±6.9)s,(24.5±12.9)s]与健康组的差异存在统计学意义(P0.05)。2)健康人群PPI的影响因素分析:单因素分析显示,健康组性别(P0.05)、吸烟量(r=0.29,P0.05)、RBANS总分(r=0.30,P0.05)、注意因子得分(r=0.29,P0.05)对PPI抑制率的影响具有统计学意义;多因素岭回归分析显示,健康组岭参数k=2.95模型稳定,R~2=0.33,PPI抑制率受到性别、吸烟量、RBANS总分、注意因子分的影响(P0.05)。3)慢性精神分裂症病人PPI的影响因素分析:单因素分析显示,病人组吸烟量(r=0.23,P0.05)、复发次数(3次vs≤3次,P0.05)对PPI抑制率的影响差异具有统计学意义;多因素岭回归分析显示,病人组岭参数k=2.58模型稳定,R~2=0.26,PPI抑制率受到性别、吸烟量和复发次数的影响(P0.05)。结论 PPI抑制率是反映感觉门控功能的指标,健康人群和慢性精神分裂症病人PPI的影响因素不尽相同。女性、吸烟可能是精神分裂症病人感觉门控的保护性因素,而发病次数过多可能对精神分裂症病人感觉门控功能有损害。
[Abstract]:Objective to explore the influencing factors of prepulse inhibition (PPI) in healthy people and patients with chronic schizophrenia. Methods 50 healthy adults (healthy group) and 75 schizophrenic patients (patient group) were tested with PPI and cognitive tests. The cognitive tests were performed with repetitive for the Assessment of neuropsychological status test (RBANS) and Stroop color-word test. The patients' mental symptoms were assessed with the positive and negative symptom scale negative Syndrome (scale PANSS). Results 1) compared with the healthy group, The inhibition rate of PPI in the patient group was decreased by 9.4% 卤29.3%vs 31.7% 卤26.2C, the total score of RBANS and its 5-factor scores, the color of Stroop and the time of word interference in the patient group (370.0 卤48.5%) were significantly lower than those in the healthy group (79.7 卤15.8 卤79.7 卤12.31.8 卤65.3 卤18.3s 24.5 卤12.9s) and the difference between the healthy group and the healthy group was statistically significant (P 0.05. 2). The univariate analysis showed that there were significant differences in PPI between the two groups. The sex of healthy group was P0.05, the total score of RBANS was 0.30 and P0.05, the score of attention factor was 0.29 and P0.05), and the multivariate ridge regression analysis showed that the inhibition rate of PPI in healthy group was controlled by sex and the total score of RBANS was 0.33% in K2.95 model, and the total score of RBANS was higher than that in control group. The influence of attention factor scores on PPI in patients with chronic schizophrenia: univariate analysis showed that there were significant differences in the inhibition rate of PPI between the two groups (P < 0. 05, P 0. 05, P 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). Multivariate ridge regression analysis showed that the inhibition rate of PPI was influenced by sex, number of smoking and relapse times in patients with KG 2.58 model. Conclusion the inhibition rate of PPI is an indicator of sensory gated function, and the influencing factors of PPI in healthy population and chronic schizophrenia patients are different. In women, smoking may be the protective factor of sensory gating in schizophrenic patients, and the frequency of onset may impair the sensory gated function of schizophrenic patients.
【作者单位】：首都医科大学附属北京安定医院精神病学系精神疾病诊断与治疗北京市重点实验室北京脑重大疾病研究院精神分裂症研究所;北京大兴区精神病医院;
【基金】：国家自然科学基金(81471365) 北京市科技计划(Z161100002616017) 北京脑重大疾病研究院(PXM2015_014226_000051)~~
【分类号】：R749.3

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