基于体素的形态学测量-自建模板及微分同胚图像融合算法评价近期发病创伤后应激障碍患者脑结构

发布时间：2018-06-12 15:08

本文选题：磁共振成像 + 应激障碍　；参考：《中国医学影像技术》2014年09期

【摘要】：目的采用基于体素形态学测量-自建模板及微分同胚图像融合(VBM-DARTEL)算法,对比近期发病创伤后应激障碍(PTSD)患者与有创伤暴露史的健康对照(TEHC)间脑结构的体积差异,分析差异脑区的体积与患者症状严重程度的相关性。方法采集地震后7~15个月右利手的地震幸存者的高分辨率三维T1WI图像,其中近期发病PTSD患者28例(PTSD组)、TEHC 28名(TEHC组)。采用MatLab 2012b工作平台下SPM8软件的VBM-DARTEL工具包预处理图像。以性别、年龄、受教育程度、地震后时间及颅内容积为协变量,对比两组间全脑灰质和白质的体积差异。以与上述相同的协变量评价差异脑区的体积与患者临床创伤后应激障碍诊断量表(CAPS)评分间的相关性。结果与TEHC组相比,PTSD组右侧舌回灰质体积增加,右侧楔叶、右侧枕中回、右侧丘脑及双侧颞上回灰质体积缩小,左侧颞上回白质体积缩小。两组间海马灰质体积差异无统计学意义。左侧颞上回灰质体积与患者CAPS评分呈负相关。结论近期发病PTSD患者结构改变以部分脑区灰白质萎缩为主。近期发病PTSD患者海马体积无萎缩可能是与病程延续数年PTSD患者不同的脑结构特征。
[Abstract]:Objective to compare the diencephalic structure of PTSD patients with recent PTSD and healthy controls with history of trauma exposure by using VBM-DARTEL algorithm based on morphometric measurement and differential homeomorphism image fusion (VBM-DARTEL). To analyze the correlation between the volume of different brain area and the severity of symptoms. Methods High-resolution 3D T1WI images of the survivors of right-handedness were collected 7 ~ 15 months after the earthquake. Among them, 28 patients with PTSD were diagnosed as PTSD patients and 28 patients were treated with TEHC. The VBM-DARTEL toolkit based on MATLAB 2012b is used to preprocess the image of SPM8 software. Sex, age, education level, time after earthquake and intracranial volume were used as covariables to compare the volume difference between the two groups in whole brain gray matter and white matter. The correlativity between the volume of different brain regions and the clinical posttraumatic stress disorder diagnostic scale (CAPSS) was evaluated with the same covariate as above. Results compared with TEHC group, the gray matter volume of right lingual gyrus increased, right wedge lobe, right middle occipital gyrus, right thalamus and bilateral superior temporal gyrus decreased, and white matter volume of left superior temporal gyrus decreased in PTSD group. There was no significant difference in hippocampal gray matter volume between the two groups. The volume of gray matter in the left superior temporal gyrus was negatively correlated with the caps score. Conclusion the structural changes of PTSD patients are mainly gray matter atrophy. The absence of atrophy of hippocampal volume in recent PTSD patients may be different from that of PTSD patients with a course of several years.
【作者单位】：四川大学华西医院放射科华西磁共振研究中心;遵义市第一人民医院放射科;中南大学湘雅二医院精神卫生研究所;
【基金】：国家自然科学基金(81030027)
【分类号】：R749.99;R445.2

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