神经生长因子联合西酞普兰对海洛因依赖者脱毒期抑郁及心理渴求症状的疗效观察

发布时间：2018-06-21 08:02

本文选题：神经心理学 + 神经生长因子　；参考：《安徽医科大学》2013年硕士论文

【摘要】：据报道全世界每年有约10万人死于吸毒，我国目前登记在册的吸毒人员有100万左右。吗啡、海洛因等毒品被人们反复使用后，会产生躯体依赖性和精神依赖性，躯体依赖性主要表现为戒断症状，精神依赖性则是药物对中枢神经系统作用后所产生的一种特殊的奖赏效应，表现为心理渴求和持续精神焦虑、抑郁障碍；而精神依赖性是导致复吸的重要原因，同时持续心理渴求、精神抑郁障碍又严重影响吸毒者的心理健康和人格健全。海洛因依赖者脱毒期抑郁症属于药物引发的继发性抑郁障碍，但目前大多数治疗方法仍然采用抗抑郁药物为主的治疗方法，另外也有采用心理认知疗法、中医中药等，虽然一定程度上在缓解海洛因依赖者脱毒期抑郁及心理渴求症状，但疗效反复，，临床治愈率低。本研究采用神经生长因子(nerve growth factor NGF）联合西酞普兰的治疗方式,从神经心理学角度积极探索治疗海洛因依赖者脱毒期抑郁症的有效方法，分析其心理渴求、抑郁症状的可能发病原因和发病机制，并为今后的戒毒治疗提供参考。目的：评价神经生长因子联合西酞普兰对海洛因依赖者的抑郁及心理渴求症状的治疗效果。方法：将93名男性患者随机分为两组，其中西酞普兰治疗组41人，神经生长因子(NGF）联合西酞普兰治疗组42人，治疗前两组罪犯的年龄、刑期及Beck抑郁自评问卷(BDI-13)评分比较均无统计学差异。除戒毒用药美沙酮及丁丙诺啡外，两组分别应用西酞普兰和神经生长因子联合西酞普兰进行治疗，疗程为6周。采用Beck抑郁自评问卷(BDI-13)、心理渴求自评量表及临床疗效总评量表(CGI)进行评定疗效。结果：神经生长因子联合西酞普兰组治疗后1、2、4、6周末BDI-13评分及减分率较西酞普兰组有明显差异(P0.05)；神经生长因子联合西酞普兰组治疗后14、21、28、35、42天末心理渴求评分较西酞普兰组明显下降(P0.05)：神经生长因子联合西酞普兰组治疗后1、2、4、6周末临床疗效总评量表(CGI)评分较西酞普兰组明显减少(P0.05)。结论：神经生长因子联合西酞普兰可有效地减轻海洛因依赖者在脱毒期抑郁及心理渴求症状。
[Abstract]:It is reported that about 100000 people die from drug abuse every year in the world, and about 1 million drug addicts are registered in our country. After repeated use of morphine, heroin and other drugs, they will produce physical and mental dependence, which is mainly manifested as withdrawal symptoms. Mental dependence is a special reward effect after the effect of drugs on the central nervous system, which is manifested by psychological craving, persistent mental anxiety and depression, and mental dependence is an important cause of relapse. At the same time, persistent psychological craving and mental depression seriously affect the mental health and personality of drug addicts. Detoxifying detoxification of heroin addicts is a secondary depressive disorder caused by drugs. However, at present, most of the treatment methods still use antidepressants as the main treatment methods, in addition, they also use psychological cognitive therapy, traditional Chinese medicine, and so on. Although the depressive and psychological craving symptoms in detoxified heroin addicts were alleviated to some extent, the curative effect was repeated and the clinical cure rate was low. In this study, nerve growth factor combined with citalopram was used to explore the effective treatment of detoxified depression in heroin addicts from the perspective of neuropsychology, and to analyze their psychological craving. The possible causes and pathogenesis of depressive symptoms, and provide reference for the future treatment of detoxification. Aim: to evaluate the effect of nerve growth factor (NGF) combined with citalopram on depression and craving symptoms in heroin addicts. Methods: 93 male patients were randomly divided into two groups: 41 in citalopram group and 42 in NGF combined with citalopram group. There was no significant difference in prison term and BDI-13 score in Beck self-assessment depression questionnaire. In addition to methadone and buprenorphine, the two groups were treated with citalopram and nerve growth factor combined with citalopram for 6 weeks. The efficacy was evaluated by Beck self-rating depression questionnaire BDI-13 psychological craving scale and General efficacy scale (CGI). Results: the BDI-13 score and score reduction rate of NGF combined with citalopram group were significantly different from those of citalopram group at the end of 6 weeks. The scores of craving at the end of 42 days in the NGF combined with citalopram group were significantly lower than those in the citalopram group at the end of 42 days. The CGI scores of NGF combined with citalopram group at the end of the week were higher than those in the citalopram group at the end of the week. In the group of Plain, the concentration of P0. 05 was significantly decreased. Conclusion: NGF combined with citalopram can effectively relieve detoxification depression and craving symptoms in heroin addicts.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.6

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