小剂量西酞普兰与多塞平治疗伴发焦虑症的共病性失眠的随机对照研究

发布时间：2018-06-22 08:30

本文选题：共病性失眠 + 入睡困难　；参考：《复旦大学》2013年硕士论文

【摘要】：研究目的对比分析小剂量西酞普兰和多塞平治疗伴发焦虑症的共病性失眠患者的有效剂量、疗效、疗程及安全性。研究方法采用随机分组的方法,将78例伴发焦虑症的共病性失眠患者分为西酞普兰组(20mg/d)和多塞平组(12.5mg/d),两组疗程均为12周。两名评定员于治疗前及治疗第4、8、12周末采用匹兹堡睡眠量指数表(PSQI,附表1)及汉密尔顿焦虑量表(HAMA,附表2)对受试者的睡眠质量及焦虑情绪进行测评,记录不良反应,并对数据进行统计学分析。研究结果 ①小剂量西酞普兰和多塞平均可以明显缩短伴发焦虑症的共病性失眠患者的入睡时间,但多塞平组患者8周末及12周末入睡时间较西酞普兰组改善更明显(P=0.002,P0.001)；②小剂量西酞普兰和多塞平均可以明显改善伴发焦虑症的共病性失眠患者的总睡眠时间、日间功能障碍、睡眠质量,两组差异无统计学意义(P0.05)；③小剂量西酞普兰组和多塞平组患者经治疗失眠状况缓解的同时,焦虑状况也得到了缓解。④小剂量西酞普兰组和多塞平组患者不良反应差异无统计学意义(P=0.404)。研究结论小剂量西酞普兰可明显改善受试者的睡眠总体水平及焦虑状况,可用于伴发焦虑症的共病性失眠长期治疗药物。小剂量多塞平十分适合做为伴发焦虑症的共病性失眠患者改善失眠及焦虑症状的药物,对于入睡困难明显的共病性失眠患者有明显疗效。
[Abstract]:research objective
To compare and analyze the effective dose, efficacy, course of treatment and safety of low dose citalopram and doxepin in the treatment of comorbid insomnia patients with anxiety disorder.
research method
78 patients with common diseased insomnia associated with anxiety were divided into 78 cases of citalopram group (20mg/d) and doxepin group (12.5mg/d). The two groups were treated for 12 weeks. Before and after the treatment, two assessors adopted the Pittsburgh sleep index table (PSQI, Appendix 1) and Hamilton Anxiety Scale (HAMA, appendix 2). The sleep quality and anxiety of the subjects were assessed, and adverse reactions were recorded, and the data were statistically analyzed.
Research results
(1) small dose of citalopram and doxer could significantly shorten the time to fall asleep in the patients with concomitant anxiety disorder, but the sleep time of the patients in the 8 and 12 weekends of the doxepin group was better than that of the citalopram group (P=0.002, P0.001); and the average dose of citalopram and doxeb in the small dose of citalopram and doxeb could significantly improve the concomitant disease of the associated anxiety disorder. There was no significant difference in the total sleep time, daytime dysfunction and sleep quality of the insomniacs (P0.05). (3) the patients in the small dose of citalopram group and doxepin group were relieved at the same time with the treatment of insomnia. (4) there was no difference in the adverse reaction between the small dose of citalopram group and the doxepin group. Meaning (P=0.404).
research conclusion
Small dose of citalopram can significantly improve the overall level of sleep and anxiety in the subjects. It can be used for the long-term treatment of concomitant insomnia. Small dose doxepin is very suitable for improving insomnia and anxiety symptoms in patients with concomitant anxiety disorder. The patient has a significant effect.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.72

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