氟哌啶醇与利培酮改善痴呆患者精神行为症状的效果比较

发布时间：2018-06-22 16:20

本文选题：氟哌啶醇 + 利培酮　；参考：《中国老年学杂志》2014年03期

【摘要】：目的比较氟哌啶醇与利培酮改善痴呆患者精神行为症状的效果。方法 2010年1月至2012年6月收治的痴呆精神行为症状患者70例按随机数字表法分为两组,每组35例。对照组给予氟哌啶醇,观察组给予利培酮,治疗12 w。治疗前后行痴呆病理行为评定表(BEHAVEAD)、简易智能状态检查(MMSE)量表评价,分别评定痴呆患者的精神行为症状及认知功能,并以副反应症状量表(TESS)评定不良反应。结果观察组患者治疗后MMSE评分显著升高(P0.05),且显著高于对照组(P0.05),而对照组治疗前后无明显变化(P0.05)。两组治疗后BEHAVEAD总分及各因子评分均较治疗前显著降低(P0.05);两组比较,观察组治疗后BEHAVE-AD总分及幻觉、行为紊乱、攻击行为评分显著低于对照组(P0.05)。观察组不良反应发生率为34.29%(12/35),对照组为51.43%(18/35),差异有统计学意义(χ2=4.46,P0.05)。结论相比氟哌啶醇,利培酮改善痴呆患者精神行为症状疗效显著,在幻觉、行为紊乱、攻击行为方面优势明显,并能改善认知功能,不良反应少,值得临床进一步推广应用。
[Abstract]:Objective to compare the effects of haloperidol and risperidone on mental and behavioral symptoms in patients with dementia. Methods from January 2010 to June 2012, 70 patients with mental and behavioral symptoms of dementia were randomly divided into two groups, 35 cases in each group. The control group was given haloperidol and the observation group was given risperidone for 12 weeks. Patients with dementia were evaluated with Behaviad scale and MMSE scale before and after treatment. The symptoms of mental behavior and cognitive function were evaluated, and adverse reactions were evaluated by Tess. Results the MMSE score in the observation group was significantly higher than that in the control group (P0.05), but there was no significant change before and after treatment in the control group (P0.05). After treatment, the total scores of BEHAVEAD and the scores of each factor in the two groups were significantly lower than those before treatment (P0.05), the total scores of BEHAVE-AD and hallucinations, behavioral disorders and aggressive behavior scores in the observation group were significantly lower than those in the control group (P0.05). The incidence of adverse reactions was 34.29% (12 / 35) in the observation group and 51.43% (18 / 35) in the control group. Conclusion compared with haloperidol, risperidone has a significant effect on improving mental behavior symptoms in dementia patients. It has obvious advantages in hallucination, behavioral disorder and aggressive behavior, and can improve cognitive function and has fewer adverse reactions. It is worthy of further clinical application.
【作者单位】：贵阳市第二人民医院神经内科;
【分类号】：R749.16

【参考文献】