不同临床相双相障碍患者血清脑源性神经营养因子水平研究

发布时间：2018-06-27 14:32

本文选题：临床相 + 双相障碍　；参考：《中国神经精神疾病杂志》2014年04期

【摘要】：目的通过比较不同临床相、不同用药状态双相障碍(bipolar disorder,BD)患者血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)水平与正常对照者的差异,以及分析BDNF水平与病程、症状严重程度的关系,以探讨BDNF在BD中的作用。方法纳入159例BD患者与41名对照,患者分为躁狂相(50例)、抑郁相(46例)、混合相(24例)及稳定期(36例)。使用汉密尔顿抑郁量表及杨氏躁狂量表评估患者症状严重程度,并测定所有研究对象的血清BDNF水平。结果患者血清BDNF水平低于对照组[(18.5±10.2)ng/mL vs.(26.0±12.9)ng/mL],差异有统计学意义(P0.001);躁狂相、抑郁相、混合相及稳定期患者血清BDNF水平差异无统计学意义(P0.05);用药及未用药患者血清BDNF水平亦无差异(P0.05)。未发现患者血清BDNF水平与病程、症状严重程度间存在相关性(P0.05)。结论不同临床相BD患者血清BDNF水平低于正常对照,与用药状态、病程、症状严重程度无关,BDNF可能可作为BD的生物学指标。
[Abstract]:Objective to compare the serum levels of brain-derived neurotrophic factor (brain derived neurotrophic factor (BDNF) in patients with bipolar disorder and normal controls in different clinical phases and different drug states, and to analyze the relationship between the levels of BDNF-BDNF and the course of disease and the severity of symptoms. To explore the role of BDNF in BD. Methods 159 BD patients and 41 controls were divided into manic phase (50 cases), depression phase (46 cases), mixed phase (24 cases) and stable phase (36 cases). The severity of symptoms was evaluated by Hamilton Depression scale and Young mania scale, and serum BDNF levels were measured in all subjects. Results the level of BDNF in serum of the patients was lower than that of the control group [(18.5 卤10.2) ng / mL vs (26.0 卤12.9) ng / mL], the difference was statistically significant (P0.001), there was no significant difference in serum BDNF levels between patients with mania, depression, mixed phase and stable phase (P0.05), and there was no difference between the patients with and without medication (P0.05). No correlation was found between serum BDNF level and course of disease and severity of symptoms (P0.05). Conclusion the serum BDNF level of BD patients in different clinical phases is lower than that of normal controls. BDNF may be used as a biological index of BD, which is not related to the state of medication, course of disease, and severity of symptoms.
【作者单位】：广州市精神病医院精神科;
【基金】：广东省科学技术厅卫生科技课题(编号:2011B031800292)
【分类号】：R749.4

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