番茄红素复合维生素E对轻度认知障碍老年人群干预的随机对照研究

发布时间：2018-07-03 12:22

本文选题：番茄红素 + 维生素E　；参考：《营养学报》2017年01期

【摘要】：目的观察番茄红素复合维生素E干预对轻度认知功能障碍(mild cognitive impairment,MCI)老人认知功能的影响并探讨其相关机制。方法募集56名MCI老年志愿者,按年龄、文化程度及MMSE测试分数匹配的原则,分为番茄红素组(30人)和安慰剂组(26人)。番茄红素组每天服用番茄红素胶囊(每粒含番茄红素10.6mg、维生素E 7.3 mg),安慰剂组服用安慰剂胶囊;每日2次,每次1粒,为期6个月。采用基本认知能力(BCAT)软件评价老人的认知功能;取血清检测IL-6、IL-10、TNF-α、us CRP、Hcy含量,以及血糖血脂水平。结果与安慰剂组比较,番茄红素组老人BCAT测试总分明显提高(P0.05);同时Hcy和IL-6水平显著降低(P0.05),而IL-10、TNF-α、us CRP浓度及血糖血脂水平无明显变化。结论番茄红素和维生素E复合制剂干预可增强MCI老人认知功能,其作用机制与降低同型半胱氨酸、减轻炎性反应有关。
[Abstract]:Objective to observe the effects of lycopene combined with vitamin E on cognitive function of the elderly with mild cognitive impairment (mild cognitive impaction) and to explore its related mechanism. Methods 56 elderly MCI volunteers were divided into lycopene group (n = 30) and placebo group (n = 26) according to their age, education level and MMSE scores. The lycopene group was given lycopene capsules (10.6 mg / L, vitamin E 7.3 mg), placebo group) and 1 capsule twice daily for 6 months. The basic cognitive ability (BCAT) software was used to evaluate the cognitive function of the elderly, and the serum levels of IL-6, IL-10, TNF- 伪, CRP- 伪, and blood glucose and blood lipid were measured. Results compared with placebo group, the total score of BCAT in lycopene group was significantly higher than that in placebo group (P0.05), while the levels of Hcy and IL-6 were significantly decreased (P0.05), while the CRP level of IL-10 TNF- 伪 and the level of blood glucose and blood lipid had no significant change. Conclusion the intervention of lycopene and vitamin E can enhance the cognitive function of MCI elderly, and its mechanism is related to the reduction of homocysteine and the abatement of inflammatory reaction.
【作者单位】：军事医学科学院卫生学环境医学研究所;首都医科大学附属北京世纪坛医院;
【基金】：汤臣倍健营养研究基金(No.TY0141101)
【分类号】：R749.1

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