自闭谱系障碍的大脑功能性连接研究进展

发布时间：2018-07-06 19:16

本文选题：自闭谱系障碍 + 功能性连接　；参考：《华南师范大学学报(自然科学版)》2014年06期

【摘要】：自闭谱系障碍是一种以早期社会交往上的广泛性异常、缺乏与人进行沟通的能力、异常局限的兴趣以及刻板重复性行为为特征的复杂的神经发育障碍.自闭谱系障碍的脑功能成像研究表明,无论是任务态下,还是静息态下,自闭谱系障碍存在着功能性连接的普遍降低,而这种神经同步性活动的异常可能与自闭谱系障碍的社会交往障碍和沟通障碍的严重程度有关.除了采用功能性磁共振成像(f MRI)对自闭谱系障碍成人的大脑皮层功能性连接进行测量外,还可以采用近红外光谱成像(f NIRS)这一较为适用于儿童和临床群体的技术,对自闭谱系障碍儿童的大脑皮层功能性连接进行测量,近红外光谱成像技术(f NIRS)作为一种光学脑成像技术,能够有效且可靠地揭示自闭谱系障碍的大脑异常功能性活动.自闭谱系障碍的大脑功能性连接,不仅是对自闭谱系障碍进行早期诊断的依据,也是对自闭谱系障碍的严重程度、预后可能性进行客观分级的指标.
[Abstract]:Autism spectrum disorders (autism spectrum disorders) are a complex neurodevelopmental disorder characterized by the lack of ability to communicate with people, abnormal interest and stereotyped repetitive behavior. The brain functional imaging study of autism spectrum disorders shows that the autism spectrum disorder under the task state or the resting state. There is a general decrease in functional connectivity, which may be associated with the severity of social interaction disorders and communication disorders in autism spectrum disorders. In addition to the use of functional magnetic resonance imaging (f MRI) to measure the functional connectivity of the cerebral cortex of adults with autism spectrum disorders, it is also possible to use the functional magnetic resonance imaging (fMRI). Near infrared imaging (f NIRS), a technique that is more suitable for children and clinical groups, is used to measure the functional connectivity of the cerebral cortex in children with autism spectrum disorders. Near infrared spectroscopy (f NIRS), as an optical brain imaging technique, can effectively and reliably reveal the abnormal functional activity of the brain of the autism spectrum disorder. The functional connection of the brain of the autism spectrum disorder is not only the basis for early diagnosis of autism spectrum disorder, but also an objective index for the severity of autism spectrum disorder and the possibility of prognosis.
【作者单位】：华南师范大学心理学院;
【基金】：广东省引进创新团队计划项目(201001D0104799318) 澳门基金会资助项目(CUM-16)
【分类号】：R749.94

【共引文献】