不同剂量米氮平联合草酸艾司西酞普兰片治疗抑郁伴焦虑的疗效分析

发布时间：2018-07-17 05:07

【摘要】：目的探讨不同剂量米氮平联合草酸艾司西酞普兰片用于抑郁伴焦虑的临床治疗效果。方法选取2015年5月—2016年5月进入宜昌市优抚医院就诊的抑郁伴焦虑患者120例,采用随机数字表法分为4组,各30例。对照组予以草酸艾司西酞普兰片治疗,A、B、C组均在对照组基础上联合米氮平治疗,剂量分别为15 mg、30 mg、45mg。观察各组患者汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分,临床疗效及不良反应。结果各组入院时HAMD、HAMA评分比较,差异无统计学意义(P0.05);治疗后1个月C组HAMD、HAMA评分低于A、B组,差异有统计学意义(P0.05);治疗后3个月A、B、C组HAMD、HAMA评分比较,差异无统计学意义(P0.05)。A、B、C组临床总有效率高于对照组,差异有统计学意义(P0.05);C组临床总有效率高于A、B组,差异有统计学意义(P0.05)。A组与对照组不良反应发生率比较,差异无统计学意义(P0.05);A组不良反应发生率低于B、C组,差异有统计学意义(P0.05)。结论不同剂量米氮平联合草酸艾司西酞普兰片用于抑郁伴焦虑治疗均可取得较好的疗效,且随着米氮平剂量的增加,可取得更佳的疗效,但不良反应也随之增加,临床可从小剂量开始,针对疗效不佳者可逐渐加量,但应观察不良反应情况。
[Abstract]:Objective to investigate the clinical effect of different doses of metozapine combined with oxalcitalopram in the treatment of depression with anxiety. Methods 120 patients with depression and anxiety were selected from May 2015 to May 2016 in Yichang City Youfu Hospital. They were randomly divided into 4 groups (30 cases each). The control group was treated with oxalcitalopram oxalate and metozapine combined with metozapine on the basis of control group, and the dosage was 15 mg / L 30 mg / L and 45 mg / g respectively. Hamilton Depression scale (Hamd), Hamilton anxiety scale (Hama), clinical efficacy and adverse reactions were observed. Results there was no significant difference in Hama score at admission in each group (P0.05), Hama score in group C was lower than that in group A (P0.05) at one month after treatment, and there was a significant difference in Hama score in group C at 3 months after treatment (P0.05), and the score of Hama in group C was significantly lower than that in group A (P0.05). There was no significant difference (P0.05). The total clinical effective rate of group A was higher than that of control group (P0.05). The total effective rate of group C was higher than that of group A (P0.05). The incidence of adverse reactions in group A was significantly higher than that in group A (P0.05). There was no significant difference (P0.05) the incidence of adverse reactions in group A was lower than that in group B (P0.05). Conclusion different doses of metozapine combined with oxalcitalopram tablets can obtain better efficacy in the treatment of depression with anxiety, and with the increase of the dose of metozapine, the better curative effect can be obtained, but the adverse reactions also increase. Clinical application can start with low dose, but the adverse reaction should be observed.
【作者单位】：湖北省宜昌市优抚医院宜昌市精神卫生中心;湖北省潜江市精神病医院;
【分类号】：R749.4

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