儿童精神分裂症神经系统软体征及其与DISC1基因rs4658971多态性的关系

发布时间：2018-07-17 18:47

【摘要】：目的调查儿童精神分裂症患者神经系统软体征(neurological soft signs,NSS)的发生状况,并探讨其与精神分裂症断裂基因1(disrupted in schizophrenia 1,DISC1)rs4658971多态性的关系。方法收集儿童精神分裂症患者146例为患者组,154名健康儿童为儿童对照组,以及160名健康成人为成人对照组。使用剑桥神经科检查软体征测试分量表评估患者组及儿童对照组的NSS,采用PCR-RFLP技术检测患者组及成人对照组DISC1 rs4658971多态性。结果患者组NSS中运动协调因子所有9项条目,以及左右皮肤书写感测验、右侧镜像运动1、扫视时头移动、眼睛闪烁等条目的阳性率均高于儿童对照(均P0.05);NSS总分、运动协调分、感觉整合分、脱抑制分均高于儿童对照(均P0.05)。携带T等位基因的患者左右序列对指运动、左右拳手掌测验、左右皮肤书写感测验、右侧镜像运动1、扫视时头移动、眼睛闪烁的阳性率,及NSS总分、运动协调分、感觉整合分、脱抑制分高于CC型患者(均P0.05)。患者组与成人对照之间DISC1 rs4658971基因型和等位基因频率差异均无统计学意义(P0.05)。结论儿童精神分裂症患者较健康儿童有明显的神经系统软体征。携带T等位基因的儿童精神分裂症患者神经系统软体征更明显。
[Abstract]:Objective to investigate the occurrence of nervous system soft sign (neurological soft) in children with schizophrenia, and to explore its association with the rs4658971 polymorphism of schizophrenia breakage gene 1 (disrupted in schizophrenia 1 (DISC1). Methods 146 children with schizophrenia were collected as control group and 154 healthy children as control group and 160 healthy adults as adult control group. The NSSs of the patient group and the control group were evaluated by Cambridge Neurology soft sign scale, and the DISC1 rs4658971 polymorphism was detected by PCR-RFLP technique in the patient group and the adult control group. Results the positive rates of all 9 items of motor coordination factor in NSS and the left and right skin writing sense test, right mirror movement 1, head movement during scanning and eye flicker were all higher than those in the control group (P0.05), the total score of NSS and motor coordination score were significantly higher than those in the control group (P0.05). The scores of sensory integration and deinhibition were higher than that of children (P0.05). The patients with T allele carried the right and left finger movement, left and right fist palm test, left and right skin writing feeling test, right mirror movement 1, the positive rate of head movement, eye flicker, and the total score of NSS, motor coordination score, sensory integration score. The decompression score was higher than that in CC type patients (P0.05). There was no significant difference in genotype and allele frequency of DISC1 rs4658971 between patients and adults (P0.05). Conclusion compared with healthy children, children with schizophrenia have obvious nervous system soft sign. Nervous system soft sign was more obvious in children with T allele.
【作者单位】：新乡医学院第二附属医院;
【基金】：河南省重点科技攻关计划项目(编号:132102310446)
【分类号】：R749.3

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