轻度认知损害及轻中度阿尔茨海默病海马亚区MRI体积的研究

发布时间：2018-07-17 17:45

【摘要】：目的探讨轻度认知损害(MCI)、轻度及中度阿尔茨海默病(AD)患者双侧海马头、体、尾各亚区体积的改变,为MCI、AD的临床早期诊疗提供影像学帮助。方法搜集MCI、轻度及中度AD患者和老年健康志愿者各20例,所有受试者均在1.5 T磁共振下行快速场回波(FFE)3D序列检查,测量并分析双侧海马整体体积及头体尾各亚区体积变化。结果左侧及右侧海马整体体积在4组间差异有统计学意义(左侧:F=61.18,P0.01;右侧:F=42.02,P0.01),且除MCI与轻度AD间差异无统计学意义外(P0.05),其余两两之间比较差异均有统计学意义。亚区体积:左侧海马头部:4组间差异有统计学意义(F=56.07,P0.01)且各组间两两比较差异均有统计学意义;右侧海马头部:4组间差异有统计学意义(F=46.19,P0.01),但两两比较时MCI与轻度AD间差异无统计学意义;左侧海马体部:4组间差异有统计学意义(F=15.65,P0.01),但两两比较时仅中度AD与其余各组间差异有统计学意义;右侧海马体部及双侧海马尾部4组间差异无统计学意义(P0.05)。结论 MCI、轻中度AD患者双侧海马整体体积及部分亚区体积存在萎缩,而对左侧海马头部的早期定量测量,将有助于对MCI、AD的早期诊断及鉴别诊断。
[Abstract]:Objective to investigate the volume changes of bilateral hippocampal head, body and tail in patients with mild cognitive impairment (MCI) and mild and moderate Alzheimer's disease (AD). Methods A total of 20 patients with MCI, 20 mild and moderate AD patients and 20 elderly healthy volunteers were examined with fast field echo (FFE) 3D sequence at 1.5 T magnetic resonance. The global volume of bilateral hippocampus and the volume changes of head, body and tail were measured and analyzed. Results the global volumes of left and right hippocampal were significantly different among the four groups (left: FFU 61.18 / P0.01; right: FN 42.02, P0.01), and there was no significant difference between MCI and mild AD (P0.05), and there were significant differences between the other two groups (P0.05). Subarea volume: there were significant differences in left hippocampal head volume among the four groups (FV 56.07U P0.01), and there were statistically significant differences between the two groups. There was a significant difference between the right hippocampal head: 4 groups (FV 46.19 / P0.01), but there was no significant difference between MCI and mild AD in pairwise comparison. There was significant difference between the left hippocampal body and the left hippocampal body (FF15. 65, P0.01), but only moderate AD had statistical significance compared with other groups, but there was no significant difference between the right hippocampal body and bilateral hippocampal tail group (P0.05). Conclusion the global volume and partial subarea volume of bilateral hippocampus in patients with MCI, mild and moderate AD are atrophied. The early quantitative measurement of the left hippocampal head will be helpful to the early diagnosis and differential diagnosis of MCI AD.
【作者单位】：江苏大学基础医学与医学技术学院;江苏大学附属宜兴人民医院放射科;江苏大学附属医院影像科;
【基金】：江苏省卫生厅科技计划资助项目(编号:H200951) 无锡市科技计划项目(编号:CSEW1N1111) 无锡市卫生局计划项目(编号:ML201320) 江苏大学临床发展基金(编号:JLY20120067)
【分类号】：R749.16;R445.2

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