轻度颅脑损伤患者执行功能障碍研究

发布时间：2018-07-18 11:13

【摘要】：目的探讨轻度颅脑损伤(mild traumatic brain injury,m TBI)患者伤后执行功能(executive function,EF)的动态变化特点。方法对63例m TBI患者(研究组)在伤后1周、1个月、3个月和6个月进行执行功能测查,并与60例健康受试者(对照组)比较。测查工具采用连线测验(trail making test,TMTA)、霍普金斯词语学习测验修订版(Hopkins verbal learning test-revised,HVLT-R)、简易视觉记忆测验—修订版(brief visuospatial memory test-revised,BVMT-R)、Stroop色词测验、持续操作测验(continuous performance test,CPT)。结果伤后1周与对照组比较,TMTA、HVLT-R、BVMT-R、Stroop和CPT-IP分值差异有统计学意义(P0.05);与伤后1周相比,伤后1个月、3个月和6个月时的TMTA分值下降,HVLT-R、BVMT-R、Stroop和CPT-IP分值增加(P0.05)。组内两两比较,伤后1个月与伤后1周比较,TMTA分值下降,BVMT-R、Stroop分值增加(P0.05);伤后3个月与伤后1个月比较,Stroop、BVMT-R和CPT-IP分值增加(P0.05);伤后6个月与伤后3个月比较,Stroop和CPTIP分值增加(P0.05)。结论m TBI患者在注意能力/警觉性、学习与工作记忆、信息处理速度及执行功能上都可能存在一定的损害,伤后不同时间点恢复速度并不一致。
[Abstract]:Objective to investigate the dynamic changes of executive function in patients with mild craniocerebral injury (mild traumatic brain injurym TBI). Methods 63 patients with m TBI (study group) were examined by executive function test at 1 week, 1 month, 3 months and 6 months after injury, and compared with 60 healthy subjects (control group). The test tools were (trail making test (TMTA), Hopkins verbal learning test-reviewed (HVLT-R), simple visual memory test (brief visuospatial memory test-viscerated BVMT-R) and Stroop word test (continuous performance test). Results there were significant differences in the scores of BVMT-Rop Stroop and CPT-IP between TMTA-HVLT-RU BVMT-RU Stroop and CPT-IP at 1 week after injury and 1 month, 3 months and 6 months after injury compared with those in control group (P0.05), and the scores of HVLT-RT-RU BVMT-RStroop and CPT-IP increased at 1 month, 3 months and 6 months after injury (P0.05). The scores of BVMT-R Stroop, Stroopus BVMT-R and CPT-IP increased at 3 months after injury and 1 month after injury (P0.05), and the scores of Stroop and CPTIP increased at 6 months after injury and 3 months after injury (P0.05). Conclusion there may be some impairment in attention / alertness, learning and working memory, information processing speed and executive function in m-TBI patients, and the recovery rate is different at different time points after injury.
【作者单位】：青海省西宁市第二人民医院脑外科;青海省西宁市第三人民医院精神科;
【基金】：青海省西宁市2015年直接补助科技计划项目课题(编号:2015-k-16)
【分类号】：R749.12

【参考文献】