多发性抽动症预后的影响因素分析

发布时间：2018-07-18 20:43

【摘要】：【目的】探讨影响多发性抽动症预后的相关因素。【方法】收集2007年1月至2010年10月在本院儿科门诊就诊的420例多发性抽动症患儿作为研究对象,总随访时间为3年。采用统一制订的调查量表,从性别、发病年龄、其母孕期情况、围生期情况、饮食偏嗜、家庭关系、首发症状、病情严重程度、基础病、共患病(注意缺陷多动障碍、焦虑障碍、强迫症等)、精神或神经病家族史、微量元素水平、脑电图、抗链球菌"O"抗体(ASO)、病程、维持治疗情况等方面对预后影响因素进行研究。应用单因素及多因素Logistic回归分析方法分析预后的相关影响因素。【结果】420例多发性抽动症患儿中,最终纳入分析396例,失访24例,失访率5.7%,其中缓解率为78.3%,未愈率为21.7%。通过单因素Logistic分析方法初步筛选影响因素,病程、出生异常病史、父亲文化程度、母亲文化程度、教养方式、精神或神经病家族史、基础病史、共患病史、ASO异常、病情严重程度、病情反复频数、西药服用史等12个因素差异有统计学意义(P0.05)。再将筛选出的12个相关因素引入多因素Logistic回归分析得出:教养方式、共患病史、病情严重程度、病情反复频数等4个因素差异有统计学意义(P0.05)。【结论】不良教养方式(过于溺爱、放纵、打骂、不民主等)、有共患病史(注意缺陷多动障碍、焦虑障碍、强迫症等),以及病情严重程度较重、病情反复较频密的患儿预后较差。
[Abstract]:[objective] to investigate the factors related to the prognosis of multiple tic syndrome. [methods] 420 children with multiple tic syndrome who were admitted to our hospital from January 2007 to October 2010 were selected as the study subjects. The total follow-up time was 3 years. Using the unified survey scale, from gender, age of onset, maternal pregnancy, perinatal period, diet preference, family relations, initial symptoms, severity of the disease, basic diseases, co-prevalence (attention deficit hyperactivity disorder, attention deficit hyperactivity disorder), Anxiety disorder, obsessive-compulsive disorder (OCD), family history of mental or neuropathy, trace element level, EEG, anti-streptococcus "O" antibody (ASO), course of disease, maintenance of treatment, etc. Using univariate and multivariate logistic regression analysis, the prognostic factors were analyzed. [results] of 420 children with multiple tic syndrome, 396 cases were included in the analysis, 24 cases lost visit, the lost visit rate was 5.7%, the remission rate was 78.3%, and the unrecovered rate was 21.7%. Univariate logistic analysis was used to preliminarily screen the influencing factors, such as course of disease, history of abnormal birth, father's education, mother's education, rearing style, family history of mental or neuropathy, basic history of disease, history of coexisting diseases and abnormal ASO. There were significant differences in the severity of the disease, the recurrence frequency of the disease, the history of western medicine use and other 12 factors (P0.05). The 12 related factors were introduced into the multivariate logistic regression analysis. The results showed that: rearing style, history of co-morbidity, severity of the disease, There were significant differences among the four factors (P0.05). [conclusion] the bad rearing style (overindulgence, indulgence, scolding, undemocracy, etc.), the history of co-infection (attention deficit hyperactivity disorder, anxiety disorder, etc.), Obsessive-compulsive disorder (OCD), as well as the severity of the disease, the disease repeated more frequently in children with poor prognosis.
【作者单位】：广东省中医院儿科;
【基金】：广东省科学技术厅科研项目(编号:2010B031600270)
【分类号】：R749.94

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