精神分裂症患者完成言语流畅性任务时前额叶脑血流变化

发布时间：2018-07-28 09:30

【摘要】：目的:采用近红外光成像技术探讨精神分裂症患者言语流畅性任务时波谱特点及其额叶激活状态。方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的精神分裂症患者99例、正常对照98例,利用近红外光成像仪(NIRS)检测其完成言语流畅性任务时额叶血流的变化。被试会依次听到3个简单的字,然后以这个字为首组成词语或成语。比较精神分裂症组和正常对照组在基线和任务期间的氧合血红蛋白和脱氧血红蛋白的浓度变化。结果:在基线状态时,精神分裂症组的氧合血红蛋白和还原血红蛋白的水平与正常对照组在额叶差异无统计学意义。言语流畅性任务期间,精神分裂症组的氧合血红蛋白平均峰值低于正常对照组[(0.19±0.02)mVmm vs.(0.34±0.03)mVmm,P0.05],氧合血红蛋白浓度达到峰值的时间明显延迟[(76.5±2.4)s vs.(44.7±2.1)s,P0.05]。在还原血红蛋白的波谱中,正常对照组的波形一直下降到基线然后上升,而精神分裂症组的波形在10 s时迅速上升到峰值,然后下降后再上升。结论:精神分裂症患者的NIRS检测波谱变化与正常对照不一致,可作为精神分裂症辅助诊断的一个客观指标。
[Abstract]:Aim: to investigate the spectral characteristics and frontal activation state of speech fluency task in schizophrenic patients by near-infrared imaging (NIR). Methods: Ninety-nine schizophrenic patients who met the diagnostic criteria of American Diagnostic and Statistical Manual for Psychiatry (DSM-IV) and 98 normal controls were selected to measure the changes of frontal blood flow during the completion of speech fluency task by near-infrared light imager (NIRS). The subjects were followed by three simple words, followed by a word or idiom. The concentrations of oxygenated hemoglobin and deoxyhemoglobin were compared between schizophrenic group and normal control group during baseline and task. Results: there was no significant difference in the levels of oxygenated hemoglobin and reduced hemoglobin between the schizophrenic group and the normal control group in the frontal lobe at baseline. During the verbal fluency task, the mean peak value of oxygenated hemoglobin in the schizophrenia group was lower than that in the normal control group [(0.19 卤0.02) mVmm vs. (, 0.34 卤0.03) mVmm-1, P0.05], and the time of the peak of the oxygenated hemoglobin concentration was significantly delayed [(76.5 卤2.4) s vs. (, 44.7 卤2.1) s-1, P0.05]. In the spectrum of reduced hemoglobin, the waveform of normal control group decreased to the baseline and then increased, while that of the schizophrenia group rose rapidly to the peak at 10 s, then decreased and then increased. Conclusion: the changes of NIRS spectrum in schizophrenic patients are not consistent with those of normal controls, and can be used as an objective index for the auxiliary diagnosis of schizophrenia.
【作者单位】：北京大学第六医院;北京大学精神卫生研究所;卫生部精神卫生学重点实验室(北京大学);
【分类号】：R749.3

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