早发精神分裂症脑白质微结构弥散张量成像的研究

发布时间：2018-08-01 10:41

【摘要】：目的:利用头颅核磁共振弥散张量成像(diffusion tensor imaging，DTI)的技术，研究早发精神分裂症的脑白质微结构的改变，探讨早发精神分裂症神经病理学基础。方法:以《精神疾病诊断与统计手册》第四版修订本（DSM-IV-TR）为诊断依据，收集山西医科大学第一医院精神卫生科2011年9月-2013年1月门诊及住院的早发精神分裂症患者26例，同时收集同一地区性别、年龄匹配的对照儿童31例。对两组被检查者进行磁共振成像扫描，，收集弥散张量成像数据，组织扩散特征的指标用部分各向异性(fractional anisotropy，FA)来表示。用基于纤维的FSL (FMRIB Software Library，http://www.fmrib.ox.ac.uk/fsl)软件包中的空间统计方法（Tract-Based Spatial Statistics，TBSS）对所得到的弥散张量成像图像进行分析。在分析开始要分别进行头动校正和涡流校正，进行全脑mask后,形成个体FA图像，将个体FA图分别配准到MNI152标准空间，是通过非线性变换的方法，最终得到一个平均的FA像，浓缩该图像后产生一个模板骨架，我们界定FA的阈值≥0.2以排除周围组织干扰，最后，采用独立样本t检验进行比较， p值小于0.01作为显著性标准。结果:与正常组对照比较，早发精神分裂症患者平均FA值升高，升高的位点位于左侧大脑半球颞中回、右侧大脑半球中央后回、左侧大脑半球颞上回和左侧大脑半球扣带后回。结论: 早发精神分裂症患者不同脑区的脑白质发生了异常。早发精神分裂症患者可能存在神经纤维代偿性再生。
[Abstract]:Objective: To study the changes in the white mass structure of early onset schizophrenia by using the technique of diffusion tensor imaging (DTI) and to explore the basis of neuropathology in early onset schizophrenia.
Methods: with the fourth edition of the psychiatric diagnosis and Statistics Manual (DSM-IV-TR) as the diagnostic basis, 26 cases of early onset schizophrenia were collected in the psychiatric department of the first hospital of the first hospital of Shanxi Medical University in January September 2011, and 31 cases of age matched control children were collected in the same area. The two groups were examined. A magnetic resonance imaging scan is performed to collect diffusion tensor imaging data. The index of tissue diffusion characteristics is represented by a partial anisotropy (fractional anisotropy, FA). A spatial statistical method (Tract-Based Spatial Statistics, TBSS) in a fiber based FSL (FMRIB Software Library, http://www.fmrib.ox.ac.uk/fsl) software package is used. After the analysis begins, the head motion correction and eddy current correction should be carried out respectively. After the whole brain mask, the individual FA image is formed. The individual FA map is registered to the MNI152 standard space respectively. It is a method of nonlinear transformation to get an average FA image, and then a template bone is produced after the image is concentrated. We defined the threshold of FA to be greater than or equal to 0.2 in order to eliminate the interference of surrounding tissues. Finally, we used independent sample t test to compare the results. The p value was less than 0.01 as the significance criterion.
Results: compared with the normal group, the average FA value of the patients with early onset schizophrenia was elevated, the elevation was located in the middle temporal gyrus of the left hemisphere, the posterior central cerebral hemisphere, the left cerebral hemisphere superior temporal gyrus and the left cerebral hemisphere cingulate.
Conclusion:
Abnormal brain white matter was found in different brain regions of patients with early onset schizophrenia.
There may be compensatory regeneration of nerve fibers in patients with early onset schizophrenia.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R749.3

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