阿戈美拉汀治疗抑郁症急性期疗效的系统评价

发布时间：2018-08-09 09:35

【摘要】：目的:系统评价阿戈美拉汀治疗抑郁症急性期的疗效,以为临床治疗提供循证参考。方法:计算机检索Cochrane图书馆、Medline、EMBase、相关期刊论文、中文科技期刊数据库、中国生物医学数据库、万方数据库以及世界卫生组织(WHO)临床试验注册平台和美国临床试验注册平台,收集阿戈美拉汀对比安慰剂治疗抑郁症急性期的随机对照试验(RCT),对符合纳入标准的临床研究进行质量评价和资料提取后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入7项RCT,合计2 378例患者。Meta分析结果显示,阿戈美拉汀组患者有效率[RR=1.43,95%CI(1.29,1.59),P0.001]、缓解率[RR=1.27,95%CI(1.03,1.57),P=0.02]均显著高于安慰剂组,抑郁量表终点评分值显著低于安慰剂组[MD=-2.92,95%C(I-3.65,-2.20),P0.001],两组比较差异均有统计学意义。结论:阿戈美拉汀治疗抑郁症急性期的疗效显著。但受纳入研究方法学质量和样本量限制,该结论有待更多设计严格、长期随访的大样本RCT加以验证。
[Abstract]:Objective: to evaluate the efficacy of agomelatin in the acute stage of depression and to provide evidence-based reference for clinical treatment. Methods: a computerized search was conducted for Cochrane Library Medline Cochrane, Chinese Journal Full-text Database, Chinese Sci-tech Journal Database, Chinese Biomedical Database, Wanfang Database, World Health Organization (WHO) Clinical trial Registration platform and American Clinical trial Registration platform. A randomized controlled trial (RCT),) was used to evaluate the quality and data of the clinical studies that met the inclusion criteria. The Meta analysis was carried out by Rev Man 5.2 statistical software after the patients were enrolled in the randomized controlled trial (RCT), which was compared with placebo in the acute stage of depression. Results: a total of 7 RCTs were included. The results of Meta-analysis in 2 378 patients showed that the effective rate of Agonelatin group was significantly higher than that of placebo group [RRN 1.43N 95 CI (1.291.59) P 0.001], and the remission rate [RRN 1.2795 CI (1.03 卤1.57) P0.02] was significantly higher than that in the placebo group. The end point score of depression scale was significantly lower than that of the placebo group [MD-2.92N 95C (I-3.65 -2.20) P 0.001], and there was significant difference between the two groups. Conclusion: the efficacy of agomelatin in the treatment of acute stage of depression is remarkable. However, limited by the quality of methodology and sample size, this conclusion needs to be verified by large sample RCT with more strict design and long-term follow-up.
【作者单位】：重庆医科大学附属儿童医院药剂科/儿童发育疾病研究教育部重点实验室;第三军医大学西南医院药剂科;四川大学华西药学院临床药学研究中心;
【分类号】：R749.4

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