合并改良电抽搐治疗对不同年龄首发精神分裂症患者认知功能的影响

发布时间：2018-08-15 13:26

【摘要】：目的探讨单纯药物治疗及合并改良电抽搐治疗(MECT)治疗对首发精神分裂症患者精神病性症状及认知功能的影响。方法选取住院治疗的首发精神分裂症患者104例,根据年龄分为低年龄组(18~26岁,n=52)和高年龄组(39~46岁,n=52),两组再根据治疗方法的不同分别分为单纯药物组和合并MECT组。对各组患者进行治疗前以及治疗后3、6、12周的阳性与阴性症状量表(PANSS)评分以及威斯康星卡片分类测验(WCST),并对其结果进行统计分析。结果治疗3周后,低年龄层合并MECT组患者PANSS减分值显著高于单纯用药组,差异有统计学意义(P0.001);治疗3周和6周后,高年龄层合并MECT组PANSS减分值也显著高于单纯用药组,差异有统计学意义(P0.001)。在治疗3周后的WCST测验中,低年龄层合并MECT组患者的完成应答数、正确应答数和完成分类数均明显高于单纯用药组,高年龄层合并MECT组患者的持续错误数明显低于单纯用药组,差异均有统计学意义(P0.05)。结论 MECT能较快改善患者的精神病性症状,并能相应提高不同年龄患者的认知功能。
[Abstract]:Objective to investigate the effects of drug therapy and modified electric convulsion therapy (MECT) on psychotic symptoms and cognitive function in patients with first-episode schizophrenia. Methods 104 inpatients with first-episode schizophrenia were divided into two groups according to their age: low age group (18 ~ 26 years old) and high age group (39 ~ 46 years old). The two groups were divided into two groups according to the different treatment methods: simple drug group and MECT group. The positive and negative symptom scale (PANSS) score and Wisconsin card sorting test (WCST),) were evaluated before treatment and 3 weeks after treatment, and the results were statistically analyzed. Results after 3 weeks of treatment, the decrease score of PANSS in the low age group with MECT was significantly higher than that in the control group (P0. 001), and after 3 weeks and 6 weeks of treatment, the PANSS minus score of the MECT group in the high age group was significantly higher than that in the control group, and that in the MECT group was significantly higher than that in the control group after 3 weeks and 6 weeks of treatment. The difference was statistically significant (P0.001). In the WCST test after 3 weeks of treatment, the number of complete responses, correct responses and the number of complete classification in the low age group with MECT were significantly higher than those in the single drug group, and the number of persistent errors in the older group with MECT was significantly lower than that in the single drug group. The difference was statistically significant (P0.05). Conclusion MECT can improve psychotic symptoms and cognitive function of patients of different ages.
【作者单位】：浙江省台州市第二人民医院精神科;上海市虹口区精神卫生中心;上海交通大学BIO-X附属长宁区精神卫生中心;上海交通大学医学院附属精神卫生中心;
【基金】：国家自然科学基金(81201057)~~
【分类号】：R749.3

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