甜梦胶囊联合帕罗西汀治疗女性更年期广泛性焦虑障碍临床疗效

发布时间：2018-08-27 18:57

【摘要】：目的研究甜梦胶囊联合帕罗西汀治疗女性更年期广泛性焦虑障碍效果及抗氧化应激反应机制。方法选择120例诊断为更年期广泛性焦虑障碍患者,未用雌激素替代治疗,随机分为对照组和治疗组各60例,对照组采用帕罗西汀治疗,治疗组在对照组基础上口服甜梦胶囊,30 d为1个疗程,对比临床效果。结果两组治疗后,汉密尔顿焦虑量表(HAMA)评分和匹兹堡睡眠质量指数量表(PSQI)评分均较治疗前明显降低,且治疗组评分低于对照组(P0.05)。治疗组的总有效率和显效程度明显优于对照组(P0.05)。两组均未出现明显药物不良反应。两组治疗前后组间血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E_2)水平比较无差异(P0.05)。两组治疗后血清超氧化物歧化酶(SOD)水平较治疗前升高,丙二醛(MDA)水平降低,且治疗组改善程度大于对照组(P0.05)。结论帕罗西汀联合甜梦胶囊治疗更年期广泛性焦虑障碍安全、有效,不依赖性激素水平改善,可能与氧化应激反应有关。
[Abstract]:Objective to study the effect of Tianmeng capsule combined with paroxetine in the treatment of female climacteric generalized anxiety disorder and the mechanism of antioxidant stress response. Methods 120 patients with menopausal generalized anxiety disorder were randomly divided into control group (n = 60) and treatment group (n = 60) without estrogen replacement therapy. The control group was treated with paroxetine. The treatment group took Tianmeng capsule 30 days as a course of treatment on the basis of the control group, and compared the clinical effect. Results after treatment, the scores of Hamilton anxiety scale (HAMA) and Pittsburgh Sleep quality Index (PSQI) were significantly lower in the treatment group than in the control group (P0.05). The total effective rate and significant effect of the treatment group were significantly better than that of the control group (P0.05). There were no obvious adverse drug reactions in both groups. The levels of serum follicle stimulating hormone (FSH),) luteinizing hormone (LH) and estradiol (E _ 2) were not different between the two groups before and after treatment (P0.05). The levels of serum superoxide dismutase (SOD) and malondialdehyde (MDA) (MDA) in the two groups were higher than those before treatment, and the improvement degree in the treatment group was higher than that in the control group (P0.05). Conclusion Paroxetine combined with Tianmeng capsule is safe and effective in the treatment of menopausal generalized anxiety disorder. It is independent of the improvement of sex hormone level and may be related to oxidative stress reaction.
【作者单位】：山东省德州市第二人民医院;
【分类号】：R749.72

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