颈动脉斑块与老年广泛性脑萎缩并发认知功能障碍的相关性研究
发布时间：2018-09-01 05:47
【摘要】：目的探讨颈动脉斑块与老年广泛性脑萎缩并发认知功能障碍的相关性。方法选择连云港市第二人民医院就诊或体检发现的中、重度广泛性脑萎缩的老年患者45例,按认知功能分为:正常组15例、轻度认知功能损害(MCI)组15例和阿尔茨海默病(AD)组15例。所有受试者均接受颈动脉斑块检测,并分析颈动脉斑块与简易智能状态检查量表(MMSE)评分的关系。结果与正常组比较,AD组和MCI组颈动脉内膜中层厚度[(IMT)(2.37±0.28)mm和(2.35±0.13)mmvs(1.76±0.09)mm]及高回声斑块[(17.71±2.30)mm2和(18.96±2.12)mm2 vs(14.25±2.29)mm2]明显增加(P0.05),MMSE评分[(5.80±3.53)分和(17.40±3.92)分vs(25.73±3.08)分]明显降低(P0.05);与MCI组比较,AD组MMSE评分明显降低(P0.05)。3组低回声及混合回声斑块平均面积差异无统计学意义(P0.05)。线性回归分析显示,IMT与MMSE评分呈负相关(P=0.000)。结论脑萎缩伴IMT或高回声斑块平均面积增多的患者易发生认知功能损害,IMT越高认知功能越低;颈部超声检查可视为老年脑萎缩患者并发认知功能损害的随访指标之一。
[Abstract]:Objective to investigate the relationship between carotid plaque and cognitive impairment in elderly patients with generalized brain atrophy. Methods Forty-five elderly patients with moderate and severe extensive brain atrophy were selected from Lianyungang second people's Hospital. According to their cognitive function, 15 patients were divided into normal group and normal group. There were 15 cases of mild cognitive impairment in (MCI) group and 15 cases of Alzheimer's disease (AD) group. All subjects were examined for carotid plaque, and the relationship between carotid plaque and (MMSE) score was analyzed. Results the intima-media thickness of carotid artery [(IMT) (2.37 卤0.28) mm and (2.35 卤0.13) mmvs (1.76 卤0.09) mm] and hyperechoic plaques [(17.71 卤2.30) mm2 and (18.96 卤2.12) mm2 vs (14.25 卤2.29) mm2] in AD group and MCI group were significantly increased (P0.05) than those in control group [(5.80 卤3.53) and (17.40 卤3.92) vs (25.73 卤3.08) mm], and the MMSE score in AD group was significantly lower than that in MCI group (P0.05). There was no significant difference in the mean area of hypoechoic plaque and mixed echo plaque between the two groups (P0.05). Linear regression analysis showed that there was a negative correlation between IMT and MMSE score (P0. 000). Conclusion patients with cerebral atrophy with IMT or hyperechoic plaque mean area increase are prone to cognitive impairment the higher the cognitive function the lower the cognitive function. Cervical ultrasonography can be regarded as one of the follow-up indicators of cognitive impairment in elderly patients with cerebral atrophy.
【作者单位】： 连云港市第二人民医院老年医学科;
【基金】：蚌埠医学院科研项目(Byky1289NF)
【分类号】：R749.16
[Abstract]:Objective to investigate the relationship between carotid plaque and cognitive impairment in elderly patients with generalized brain atrophy. Methods Forty-five elderly patients with moderate and severe extensive brain atrophy were selected from Lianyungang second people's Hospital. According to their cognitive function, 15 patients were divided into normal group and normal group. There were 15 cases of mild cognitive impairment in (MCI) group and 15 cases of Alzheimer's disease (AD) group. All subjects were examined for carotid plaque, and the relationship between carotid plaque and (MMSE) score was analyzed. Results the intima-media thickness of carotid artery [(IMT) (2.37 卤0.28) mm and (2.35 卤0.13) mmvs (1.76 卤0.09) mm] and hyperechoic plaques [(17.71 卤2.30) mm2 and (18.96 卤2.12) mm2 vs (14.25 卤2.29) mm2] in AD group and MCI group were significantly increased (P0.05) than those in control group [(5.80 卤3.53) and (17.40 卤3.92) vs (25.73 卤3.08) mm], and the MMSE score in AD group was significantly lower than that in MCI group (P0.05). There was no significant difference in the mean area of hypoechoic plaque and mixed echo plaque between the two groups (P0.05). Linear regression analysis showed that there was a negative correlation between IMT and MMSE score (P0. 000). Conclusion patients with cerebral atrophy with IMT or hyperechoic plaque mean area increase are prone to cognitive impairment the higher the cognitive function the lower the cognitive function. Cervical ultrasonography can be regarded as one of the follow-up indicators of cognitive impairment in elderly patients with cerebral atrophy.
【作者单位】： 连云港市第二人民医院老年医学科;
【基金】：蚌埠医学院科研项目(Byky1289NF)
【分类号】：R749.16
【共引文献】
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