有氧训练对阿尔茨海默病的干预作用研究

发布时间：2018-09-04 10:25

【摘要】：目的:探讨有氧训练对阿尔茨海默病(AD)患者的治疗作用。方法:将60例AD患者分为有氧训练组(30例)和对照组(30例),所有入组患者均按AD常规治疗,试验组接受强度分别为50%—70%最大强度的16周有氧训练,每次持续60—90min,每周3次。分别在治疗前、8周和16周后利用简明精神状态量表(MMSE)、日常生活能力量表(ADCS-ADL)和生活质量量表(QOL-AD)对两组患者进行认知功能、ADL能力、生活质量评价,并在治疗前和治疗16周后利用临床医生面谈印象变化量表(CIBIC plus)对AD患者临床总体印象变化进行评价。结果:试验组有3例患者未完成规定的有氧训练;有氧训练对患者的血尿常规、心电图及血生化指标无显著影响(P0.05);与对照组相比,有氧训练组MMSE评分、ADCS-ADL评分和QOL评分在8周和16周均较基线明显改善(P0.05);有氧训练组在第16周时ADCS-ADL评分较第8周时明显降低(P0.05);16周时,试验组患者总体临床印象变化CIBIC plus改善率是对照组患者的3.5倍。结论:有氧训练疗法可显著改善AD患者认知功能、ADL能力、生活质量和临床总体印象,有氧训练可以作为AD辅助治疗的有效手段。
[Abstract]:Objective: to investigate the therapeutic effect of aerobic training on (AD) patients with Alzheimer's disease. Methods: 60 patients with AD were divided into aerobic training group (n = 30) and control group (n = 30). All the patients in the study group were treated with routine AD. The experimental group received 16-week aerobic training with maximum intensity of 50-70%, lasting 60-90 min, three times a week. The cognitive function and quality of life (QOL) were evaluated by the Concise Mental State scale (ADCS-ADL) and the quality of Life scale (QOL-AD) at 8 weeks and 16 weeks before treatment, respectively. The changes of general clinical impressions in patients with AD were evaluated by (CIBIC plus) before and 16 weeks after treatment. Results: three patients in the trial group did not complete the required aerobic training, and aerobic training had no significant effect on the blood urine routine, electrocardiogram and blood biochemical indexes (P0.05). The MMSE score and QOL score of aerobic training group were significantly improved compared with baseline at 8 and 16 weeks (P0.05), the ADCS-ADL score in aerobic training group was significantly lower than that in 8th week (P0.05) and that in aerobic training group was significantly lower than that in week 8 (P0.05). The CIBIC plus improvement rate of the patients in the trial group was 3. 5 times higher than that in the control group. Conclusion: aerobic training therapy can significantly improve the cognitive function, quality of life and overall clinical impression of AD patients. Aerobic training can be used as an effective means of adjuvant treatment of AD.
【作者单位】：南京医科大学第一附属医院神经内科;南京医科大学第一附属医院康复医学科;马鞍山市中心医院神经内科;
【基金】：国家自然科学基金(30901578) 江苏省“六大人才高峰”第八批高层次人才资助项目江苏省高校“青蓝工程”中青年学术带头人培养对象项目(JX2161015003) 江苏省卫生厅“科教兴卫工程”重点人才项目(RC2011072);江苏省卫生厅“科教兴卫工程”开放课题(XK20200905) 苏州市科技局科技发展计划项目(SYSD2011044)
【分类号】：R749.16;R493

【相似文献】