皮质下血管认知障碍早期注意损害的关联性负变研究
发布时间：2018-09-04 10:41
【摘要】：目的观察皮质下缺血性血管性认知损害(subcortical ischemic vascular cognitive impairment,SIVCI)患者关联性负变(contingent negative variation,CNV)变化特征及其与计算机辅助测验-持续操作任务(continuous performance task,CPT)的相关性,探求反映SIVCI早期注意损害的神经电生理指标,促进诊断水平的提高。方法应用意大利EB-Neuro事件相关电位工作站,对15例皮质下缺血性血管性痴呆(subcortical ischemic vascular dementia,SIVD)患者,30例皮质下缺血性血管性认知损害非痴呆型(subcortical ischemic vascular cognitive impairment no dementia,SIVCIND)患者和15名正常对照(normal control,NC)检测CNV命令信号前期待波(expectancy wave,EW)的潜伏期、波幅和面积。结果①与正常对照相比,SIVCI患者CNV波形欠规则;SIVCIND患者CNV EW波幅降低(9.98±4.10μV vs.16.13±2.75μV,P0.05),平均面积减少(14848.10±3199.16μV·ms vs.20058.87±1025.95μV·ms(P0.05),潜伏期差异无统计学意义(F(2,57)=1.90,P0.05);SIVD患者较SIVCIND患者EW波幅进一步降低(6.25±1.52μV vs.9.98±4.10μV,P0.05),平均面积进一步减少(8474.00±3511.94 vs.14848.10±3199.16μV·ms,P0.05);②EW潜伏期与CPT反应时呈正相关(R=0.748,P0.01),与CPT漏报率无相关性(R=0.22,P0.05);EW波幅与CPT反应时呈负相关(R=-0.616,P0.01),与CPT漏报率无相关性(R=-0.191,P0.05);EW平均面积与CPT反应时呈负相关(R=-0.718,P0.01);与CPT漏报率呈负相关(R=-0.829,P0.01)。结论 SIVCI患者早期可能即存在注意保持等认知异常;CNV EW平均面积可能为一个较好反映持续注意损害的神经电生理指标。
[Abstract]:Objective to observe the change of (contingent negative variation,CNV in patients with subcortical ischemic vascular cognitive impairment (subcortical ischemic vascular cognitive impairment,SIVCI) and its correlation with computer-assisted test (continuous performance task,CPT). To explore the neurophysiological indexes reflecting the early attention damage in SIVCI and to improve the diagnostic level. Methods EB-Neuro event-related potential workstation was used in Italy. The latent period of CNV signal Pre-expectation Wave (expectancy wave,EW) was measured in 15 patients with subcortical ischemic vascular dementia (subcortical ischemic vascular dementia,SIVD) and 30 patients with subcortical ischemic vascular cognitive impairment (subcortical ischemic vascular cognitive impairment no dementia,SIVCIND) and 15 normal controls (normal control,NC). Amplitude and area. Results 1Compared with the normal control, the amplitude of CNV EW and the average area of CNV in the patients with SIVCI were decreased (9.98 卤4.10 渭 V vs.16.13 卤2.75 渭 V P 0.05), and the mean area was decreased (14848.10 卤3199.16 渭 V ms vs.20058.87 卤1025.95 渭 V ms (P 0.05). There was no significant difference in the latency between the two groups. The EW amplitude in the patients with SIVCI was further lower than that in the patients with SIVCIND (6.25 卤1.52 渭 V, P 0.05 卤4.10 渭 V, P 0.05), and the mean area of EW in the patients with SIVCI was significantly lower than that in the patients with SIVCIND (6.25 卤1.52 渭 V, P 0.05 卤4.10 渭 V, P 0.05). Further reduction of (8474.00 卤3511.94 vs.14848.10 卤3199.16 渭 V ms,P0.05) 2EW latency was positively correlated with CPT response time (RP0. 748% P0.01), but not correlated with CPT underreporting rate (R0. 22% P05). EW amplitude was negatively correlated with CPT response time (RP0. 616, P0.01), but not with CPT underreporting rate (RP05-0. 191). EW mean area was negatively correlated with CPT reaction time (R0. 718, P0.01). The rate of missing report was negatively correlated (RV-0. 829, P0.01). Conclusion the average area of EW in patients with SIVCI may be an early neurophysiological index reflecting the impairment of sustained attention.
【作者单位】： 第三军医大学新桥医院神经内科;
【分类号】：R749.13
[Abstract]:Objective to observe the change of (contingent negative variation,CNV in patients with subcortical ischemic vascular cognitive impairment (subcortical ischemic vascular cognitive impairment,SIVCI) and its correlation with computer-assisted test (continuous performance task,CPT). To explore the neurophysiological indexes reflecting the early attention damage in SIVCI and to improve the diagnostic level. Methods EB-Neuro event-related potential workstation was used in Italy. The latent period of CNV signal Pre-expectation Wave (expectancy wave,EW) was measured in 15 patients with subcortical ischemic vascular dementia (subcortical ischemic vascular dementia,SIVD) and 30 patients with subcortical ischemic vascular cognitive impairment (subcortical ischemic vascular cognitive impairment no dementia,SIVCIND) and 15 normal controls (normal control,NC). Amplitude and area. Results 1Compared with the normal control, the amplitude of CNV EW and the average area of CNV in the patients with SIVCI were decreased (9.98 卤4.10 渭 V vs.16.13 卤2.75 渭 V P 0.05), and the mean area was decreased (14848.10 卤3199.16 渭 V ms vs.20058.87 卤1025.95 渭 V ms (P 0.05). There was no significant difference in the latency between the two groups. The EW amplitude in the patients with SIVCI was further lower than that in the patients with SIVCIND (6.25 卤1.52 渭 V, P 0.05 卤4.10 渭 V, P 0.05), and the mean area of EW in the patients with SIVCI was significantly lower than that in the patients with SIVCIND (6.25 卤1.52 渭 V, P 0.05 卤4.10 渭 V, P 0.05). Further reduction of (8474.00 卤3511.94 vs.14848.10 卤3199.16 渭 V ms,P0.05) 2EW latency was positively correlated with CPT response time (RP0. 748% P0.01), but not correlated with CPT underreporting rate (R0. 22% P05). EW amplitude was negatively correlated with CPT response time (RP0. 616, P0.01), but not with CPT underreporting rate (RP05-0. 191). EW mean area was negatively correlated with CPT reaction time (R0. 718, P0.01). The rate of missing report was negatively correlated (RV-0. 829, P0.01). Conclusion the average area of EW in patients with SIVCI may be an early neurophysiological index reflecting the impairment of sustained attention.
【作者单位】： 第三军医大学新桥医院神经内科;
【分类号】：R749.13
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