西酞普兰与多塞平治疗广泛性焦虑障碍的疗效差异研究
发布时间：2018-09-09 10:52
【摘要】：研究目的 观察小剂量西酞普兰与小剂量多塞平治疗广泛性焦虑障碍的有效剂量、疗效和临床安全性,以及两种药物的临床作用之间的差异性。 研究方法 将78例符合广泛性焦虑障碍(GAD)诊断标准的门诊患者,按就诊的先后顺序随机分为两组,分别口服西酞普兰(20mg)和多塞平(12.5mg)连续治疗12周,于治疗前、治疗4周、8周、12周后分别用汉密尔顿焦虑量表(HAMA)、精神性焦虑因子(F1)、躯体性焦虑因子(F2)、汉密尔顿抑郁量表(HAMD)对患者进行评分,观察不同治疗时间两组GAD患者HAMA、F1、F2、HAMD评分的变化,进一步分析不同治疗时间上两组药物对GAD患者的作用；在治疗终点,计算两组药物治疗GAD患者关于HAMA的痊愈率、显效率、有效率,对比分析两组药物对于GAD患者的疗效差异性；此外,还观察了治疗过程中患者出现的不良反应发生率,评估其临床安全性。 研究结果 与治疗前相比,两组患者治疗后HAMA、F1、F2、HAMD评分较治疗前降低(P0.05),并随着治疗时间的延长下降趋势逐渐显著(P0.01),组内对照采用方差分析,差异均有统计学意义；在治疗后12周时,两组药物临床总体疗效及不良反应发生率之间差异均无统计学意义。 研究结论 通过上述研究结果,我们发现,通过两组之间的总体疗效评估结果,我们认为小剂量西酞普兰和小剂量多塞平治疗广泛性焦虑障碍均具有较好的作用,两种药物总体疗效无明显差异性,且两种药物的临床安全性均较好。
[Abstract]:Objective to observe the efficacy, efficacy and safety of low dose citalopram and low dose doxepin in the treatment of generalized anxiety disorder. Methods Seventy-eight outpatients with generalized anxiety disorder (GAD) were randomly divided into two groups: oral citalopram (20mg) and doxepin (12.5mg) for 12 weeks. After 4 weeks, 8 weeks and 12 weeks of treatment, the patients were assessed with Hamilton anxiety scale (HAMA), (HAMA), mental anxiety factor (F1), somatic anxiety factor (F2) and Hamilton depression scale (HAMD) respectively. The changes of HAMA,F1,F2,HAMD score in two groups of GAD patients were observed. At the end of the treatment, the cure rate, effective rate and effective rate of HAMA in the patients with GAD were calculated, and the difference of the curative effect between the two groups for GAD patients was compared. In addition, the incidence of adverse reactions in the course of treatment was observed and its clinical safety was evaluated. Results compared with before treatment, the HAMA,F1,F2,HAMD score of the two groups was lower than that before treatment (P0.05), and with the prolongation of the treatment time, the trend of decrease was gradually significant (P0.01). The variance analysis was used in the control group, the difference was statistically significant. At 12 weeks after treatment, there was no significant difference in the overall efficacy and incidence of adverse reactions between the two groups. Conclusion based on the above results, we found that both low dose citalopram and low dose doxepin were effective in the treatment of generalized anxiety disorder. There was no significant difference in the overall efficacy of the two drugs, and the clinical safety of the two drugs was good.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.72
本文编号：2232171
[Abstract]:Objective to observe the efficacy, efficacy and safety of low dose citalopram and low dose doxepin in the treatment of generalized anxiety disorder. Methods Seventy-eight outpatients with generalized anxiety disorder (GAD) were randomly divided into two groups: oral citalopram (20mg) and doxepin (12.5mg) for 12 weeks. After 4 weeks, 8 weeks and 12 weeks of treatment, the patients were assessed with Hamilton anxiety scale (HAMA), (HAMA), mental anxiety factor (F1), somatic anxiety factor (F2) and Hamilton depression scale (HAMD) respectively. The changes of HAMA,F1,F2,HAMD score in two groups of GAD patients were observed. At the end of the treatment, the cure rate, effective rate and effective rate of HAMA in the patients with GAD were calculated, and the difference of the curative effect between the two groups for GAD patients was compared. In addition, the incidence of adverse reactions in the course of treatment was observed and its clinical safety was evaluated. Results compared with before treatment, the HAMA,F1,F2,HAMD score of the two groups was lower than that before treatment (P0.05), and with the prolongation of the treatment time, the trend of decrease was gradually significant (P0.01). The variance analysis was used in the control group, the difference was statistically significant. At 12 weeks after treatment, there was no significant difference in the overall efficacy and incidence of adverse reactions between the two groups. Conclusion based on the above results, we found that both low dose citalopram and low dose doxepin were effective in the treatment of generalized anxiety disorder. There was no significant difference in the overall efficacy of the two drugs, and the clinical safety of the two drugs was good.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.72
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