额颞叶变性的异质性
发布时间：2018-09-09 18:12
【摘要】：额颞叶变性(frontotemporal lobar degeneration,FTLD)是一组常见的痴呆症候群,尤其是在小于65岁的患者中。它包括一组以进行性行为异常、执行功能障碍或语言损害为主要特征的神经退行性疾病。因其潜在基因和病理的多样性,FTLD表现为多种临床表型,且其临床和神经影像表现呈现不同程度的重叠。额颞叶变性临床、基因、病理的异质性为早期正确诊断、精准治疗疾病提出了极大挑战。
[Abstract]:Frontotemporal lobe degeneration (frontotemporal lobar degeneration,FTLD) is a common group of dementia, especially in patients under 65 years of age. It consists of a group of neurodegenerative diseases characterized by progressive behavioral abnormalities, executive dysfunction or language impairment. Because of the diversity of its potential gene and pathology, FTLD presents a variety of clinical phenotypes, and its clinical and neuroimaging manifestations show different degrees of overlap. The clinical, genetic and pathological heterogeneity of frontotemporal lobe degeneration presents a great challenge for early correct diagnosis and accurate treatment of diseases.
【作者单位】： 中国人民解放军总医院南楼神经内科;
【分类号】：R749.1
本文编号：2233174
[Abstract]:Frontotemporal lobe degeneration (frontotemporal lobar degeneration,FTLD) is a common group of dementia, especially in patients under 65 years of age. It consists of a group of neurodegenerative diseases characterized by progressive behavioral abnormalities, executive dysfunction or language impairment. Because of the diversity of its potential gene and pathology, FTLD presents a variety of clinical phenotypes, and its clinical and neuroimaging manifestations show different degrees of overlap. The clinical, genetic and pathological heterogeneity of frontotemporal lobe degeneration presents a great challenge for early correct diagnosis and accurate treatment of diseases.
【作者单位】： 中国人民解放军总医院南楼神经内科;
【分类号】：R749.1
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