老年轻度认知功能障碍患者血清25-羟维生素D水平变化及其临床意义
发布时间：2018-09-11 12:43
【摘要】：目的观察老年轻度认知功能障碍(MCI)患者与认知功能正常(NC)老年人相比其血清25-羟维生素D[25(OH)D]水平的变化,并探讨其临床意义。方法符合入组标准的老年人共148例,采用协和版蒙特利尔认知评估量表(Mo CA-P)评估其认知功能。根据2003年国家神经系统疾病和中风研究所即NINDS及国际神经科学协会即AIREN修订的MCI诊断标准,将入组的148例老年人分为NC组和MCI组,检测比较两组血清25(OH)D水平,分析血清25(OH)D水平与老年人MCI的相关性,用受试者工作特征曲线(ROC)评价血清25(OH)D水平对老年人MCI的预测价值。结果 MCI组(72例)、NC组(76例)血清25(OH)D水平分别为(33.43±15.04)nmol/L和(41.55±17.53)nmol/L,两组相比,P0.01;25(OH)D缺乏者MCI组64例(88.9%)、NC组51例(67.1%),两组相比,P0.01。血清25(OH)D水平与Mo CA评分呈正相关(r=0.219,P0.01),25(OH)D缺乏者较25(OH)D非缺乏者发生MCI风险高(OR=3.816,P0.01)。血清25(OH)D水平降低对预测老年人MCI有一定价值[ROC的曲线下面积为0.637(95%CI为0.548~0.727),P0.01];血清25(OH)D水平联合受教育年限、年龄对老年人MCI预测价值更高[ROC的曲线下面积为0.723(95%CI为0.642~0.804),P0.01]。结论老年MCI患者血清25(OH)D水平降低,血清25(OH)D水平降低与老年人MCI的发生相关,25(OH)D缺乏老年人发生MCI风险高,检测血清25(OH)D可能有助于对老年人MCI的预测。
[Abstract]:Objective to observe the changes of serum 25 hydroxyvitamin D [25 (OH) D] levels in elderly patients with mild cognitive impairment (MCI) compared with those with normal (NC), and to explore its clinical significance. Methods one hundred and forty-eight elderly patients who met the criteria were assessed with Concord Montreal Cognitive Assessment scale (Mo CA-P). According to the MCI diagnostic criteria revised by the National Institute of Neurologic Diseases and Stroke (NINDS) and the International Association of Neuroscience (AIREN) in 2003, 148 elderly patients were divided into NC group and MCI group. The serum 25 (OH) D levels were measured and compared between the two groups. The correlation between serum 25 (OH) D level and elderly MCI was analyzed, and the predictive value of serum 25 (OH) D level to elderly MCI was evaluated by (ROC). Results the levels of serum 25 (OH) D in 72 cases of MCI group (72 cases) and 76 cases of NC group were (33.43 卤15.04) nmol/L and (41.55 卤17.53) nmol/L, respectively, compared with those of MCI group (64 cases (88.9%), 51 cases (67.1%) of NC group and (41.55 卤17.53) nmol/L, group respectively. There was a positive correlation between serum 25 (OH) D level and Mo CA score (r = 0.219 / P0.01). MCI risk (OR=3.816,P0.01) was higher in patients with 25 (OH) D deficiency than in non-deficient 25 (OH) D patients. The decrease of serum 25 (OH) D level had a certain value in predicting MCI in the elderly [the area under the ROC curve was 0.637 (95%CI = 0.548 卤0.727) P0.01], and the age of 25 (OH) D level combined with education years was higher than that of age [the area under the ROC curve was 0.723 (95%CI = 0.642 卤0.804) P0.01]. Conclusion the level of serum 25 (OH) D and the level of serum 25 (OH) D are lower in elderly patients with MCI and the risk of MCI is higher in the elderly with 25 (OH) D deficiency. The detection of serum 25 (OH) D may be helpful to predict MCI in the elderly.
【作者单位】： 北京大学人民医院;
【基金】：北京市科技计划项目(Z161100000116095)
【分类号】：R749.1
[Abstract]:Objective to observe the changes of serum 25 hydroxyvitamin D [25 (OH) D] levels in elderly patients with mild cognitive impairment (MCI) compared with those with normal (NC), and to explore its clinical significance. Methods one hundred and forty-eight elderly patients who met the criteria were assessed with Concord Montreal Cognitive Assessment scale (Mo CA-P). According to the MCI diagnostic criteria revised by the National Institute of Neurologic Diseases and Stroke (NINDS) and the International Association of Neuroscience (AIREN) in 2003, 148 elderly patients were divided into NC group and MCI group. The serum 25 (OH) D levels were measured and compared between the two groups. The correlation between serum 25 (OH) D level and elderly MCI was analyzed, and the predictive value of serum 25 (OH) D level to elderly MCI was evaluated by (ROC). Results the levels of serum 25 (OH) D in 72 cases of MCI group (72 cases) and 76 cases of NC group were (33.43 卤15.04) nmol/L and (41.55 卤17.53) nmol/L, respectively, compared with those of MCI group (64 cases (88.9%), 51 cases (67.1%) of NC group and (41.55 卤17.53) nmol/L, group respectively. There was a positive correlation between serum 25 (OH) D level and Mo CA score (r = 0.219 / P0.01). MCI risk (OR=3.816,P0.01) was higher in patients with 25 (OH) D deficiency than in non-deficient 25 (OH) D patients. The decrease of serum 25 (OH) D level had a certain value in predicting MCI in the elderly [the area under the ROC curve was 0.637 (95%CI = 0.548 卤0.727) P0.01], and the age of 25 (OH) D level combined with education years was higher than that of age [the area under the ROC curve was 0.723 (95%CI = 0.642 卤0.804) P0.01]. Conclusion the level of serum 25 (OH) D and the level of serum 25 (OH) D are lower in elderly patients with MCI and the risk of MCI is higher in the elderly with 25 (OH) D deficiency. The detection of serum 25 (OH) D may be helpful to predict MCI in the elderly.
【作者单位】： 北京大学人民医院;
【基金】：北京市科技计划项目(Z161100000116095)
【分类号】：R749.1
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