青少年抑郁情绪影响因素的双生子研究

发布时间：2018-09-14 16:03

【摘要】：目的探讨遗传及环境因素对青少年抑郁情绪的影响。方法采用贝克抑郁量表(Beck depression inventory,BDI)对重庆市107对11~18岁双生子的抑郁情绪进行评定,采用一般情况问卷、父母的养育方式和维度问卷(parenting styles and dimensions questionaire,PSDQ)、家庭压力问卷(family stresses questionnaire,FSQ)、家庭亲密度与适应性量表(family adaptability and cohesion evaluation scale 2nd edition Chinese version,FACES II-CV)、应激生活事件(stressful life event,SLE)等量表调查环境因素,采集双生子静脉血标本提取DNA以进行卵型鉴定。构建单因素结构方程模型,分析加性遗传因素(A)、共享环境因素(C)、特殊环境因素(E)对双生子抑郁情绪的影响。结果双生子的抑郁情绪与父亲受教育程度(r=-0.15,P=0.03)、母亲受教育程度(r=-0.17,P=0.01)、权威型养育方式(r=-0.18,P0.01)、家庭适应性(r=-0.27,P0.01)及亲密度(r=-0.20,P0.01)呈负相关,与家庭压力呈正相关(r=0.12,P=0.04),与应激生活事件无统计学相关性(P0.05)。结构方程示,在抑郁情绪总变异方差中加性遗传效应占0.37(95%CI:0.14~0.57),个体特殊环境因素占0.63(95%CI:0.43~0.86)。结论抑郁情绪与父母权威型养育方式、家庭适应性负性相关,与家庭压力正性相关;青少年抑郁情绪受加性遗传和特殊环境因素的共同影响,但受特殊环境的影响更大。
[Abstract]:Objective to investigate the effects of genetic and environmental factors on adolescent depression. Methods the depression of 1118 year old twins in Chongqing was assessed by Baker Depression scale (Beck depression inventory,BDI), and the general condition questionnaire was used. Parental rearing style and dimension questionnaire (parenting styles and dimensions questionaire,PSDQ), family stress questionnaire (family stresses questionnaire,FSQ), family cohesion and adaptability scale (family adaptability and cohesion evaluation scale 2nd edition Chinese version,FACES II-CV) and stress life events (stressful life event,SLE) were used to investigate environmental factors. DNA was extracted from the blood samples of Gemini vein for egg identification. A univariate structural equation model was established to analyze the effects of additive genetic factor (A), shared environmental factor (C), special environmental factor (E) on depression in twins. Results the depression of twin children was negatively correlated with their father's education level (r-0.15P0.03), mother's education level (r-0.17), authoritative rearing style (r-0.18p0.01), family adaptability (r-0.27g / P0.01) and affinity (r-0.20P0.01), but positively correlated with family stress (r = 0.12P0.04), but not correlated with stress life events (P0.05). The structural equation showed that the additive genetic effect was 0. 37 (95%CI:0.14~0.57) and the individual special environmental factor was 0. 63 (95%CI:0.43~0.86) in the total variance of depression mood. Conclusion Depression is correlated with parental authoritative rearing style, family adaptability and family stress, and adolescent depression is affected by additive inheritance and special environmental factors, but is more affected by special environment.
【作者单位】：重庆医科大学附属第一医院护理学院;重庆医科大学附属第一医院心理卫生中心;遵义医学院附属医院;四川大学华西医院心理卫生中心;陕西省榆林市第一医院;
【基金】：国家自然科学基金(编号:81101025) 重庆市医学科研计划项目(编号:20142023)
【分类号】：R749.4

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