脑源性神经营养因子基因功能性多态rs6265与散发性阿尔茨海默病的相关性

发布时间：2018-09-18 18:28

【摘要】：目的探讨脑源性神经营养因子(BDNF)基因功能性多态(rs6265)与散发性阿尔茨海默病(SAD)发病的相关性。方法选取58例SAD患者(SAD组)与52例健康老年人(对照组),用聚合酶链反应-限制性片段长度多态性技术,对BDNF基因rs6265进行检测,同时利用酶联免疫吸附技术对两组患者的血清BDNF水平进行检测。结果在65岁的人群中,等位基因(χ2=6.059 5,P=0.013)及基因型(χ2=6.082 6,P=0.0478)在两组人群中的分布有显著差异,并且SAD组AA基因型患者的血清BDNF水平最低〔(14.32±4.21)ng/ml,F=7.254 5,P=0.001 6〕。结论BDNF基因功能性多态rs6265与SAD发病相关,并且影响其血清BDNF的表达。
[Abstract]:Objective to investigate the relationship between functional polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene and sporadic Alzheimer's disease (SAD). Methods BDNF gene rs6265 was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR) in 58 patients with SAD (SAD group) and 52 healthy elderly (control group). At the same time, the serum BDNF level of the two groups was detected by enzyme linked immunosorbent assay (Elisa). Results there was a significant difference in the distribution of alleles (蠂 ~ 2 + 6.059 5) and genotype (蠂 ~ 2 + 6.082 ~ (6) P ~ (0.0478) between the two groups, and the lowest level of serum BDNF in patients with AA genotype in SAD group (14.32 卤4.21) ng/ml,F=7.254 5P0.001 6). Conclusion functional polymorphic rs6265 of BDNF gene is associated with the pathogenesis of SAD and affects the expression of BDNF in serum.
【作者单位】：广西医科大学第一附属医院神经内科;南宁残疾儿童康复中心;
【基金】：广西科学青年基金资助项目(桂科青0991036)
【分类号】：R749.16

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