可乐定透皮贴片治疗儿童抽动障碍的前瞻性、开放性临床研究

发布时间：2018-10-08 08:38

【摘要】：目的:探讨可乐定透皮贴片治疗抽动障碍的疗效和安全,建立可乐定透皮贴剂治疗对象的预测模型。方法:选择41例符合纳入标准的抽动障碍患儿,采用前瞻性、开放性、单组、自身前后对照方法,给予可乐定透皮贴片治疗12周,分别在入组时、4周、8周、12周用耶鲁抽动症整体严重程度量表进行评估。结果:⑴可乐定透皮贴剂治疗4周、8周、12周时,总有效率分别为29.27%、53.66%、63.41%,与入组时相比有显著统计学差异。⑵治疗4周和8周时,运动性抽动、发声性抽动、总抽动症状和功能损害4项因子的减分率与25%水平相比,均无统计学差异。治疗12周时,运动性抽动及总抽动症状减分率与25%水平相比,有统计学差异。⑶病程≤24个月,入组时运动性抽动评分16,有效率为100%;病程≤24个月,运动性抽动评分≥16,有效率为57.1%;病程24个月,临床分型为慢性抽动障碍,有效率为62.5%;病程24个月,临床分型为抽动秽语综合征,无效率为90%。⑷不良反应主要为贴片处皮疹、轻微头晕头痛。结论:⑴多巴胺D2受体阻滞剂治疗效果不佳的抽动障碍患儿,换用可乐定治疗依然可能有效而安全。⑵可乐定透皮贴片可作为轻中型、以运动性抽动为主要表现的患儿的首选药。
[Abstract]:Objective: to investigate the efficacy and safety of clonidine transdermal patch in the treatment of tic disorder and to establish a predictive model of clonidine transdermal patch. Methods: 41 children with tic disorders who met the inclusion criteria were treated with clonidine transdermal patch for 12 weeks. The patients were evaluated with Yale holistic severity scale at 4 weeks, 8 weeks and 12 weeks after admission. Results the total effective rates were 29.27% 53.66 and 63.41 respectively at 4 weeks and 8 weeks and 12 weeks after treatment with 1: 1 clonidine patch. There was significant difference between the two groups at 4 weeks and 8 weeks after treatment, the total effective rates were motor twitch and vocal twitch, and the total effective rates were 29. 27%, 53. 66% and 63. 41% at 4 and 8 weeks after treatment respectively, and there was significant difference between the two groups at 4 and 8 weeks. There was no statistical difference between the four factors of total tic symptoms and functional impairment compared with the 25% level. After 12 weeks of treatment, the reduction rate of motor tic and total tic symptoms was significantly lower than that of 25%, the course of disease was less than 24 months, the effective rate was 100, the course of disease was 鈮，

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