天津蓟县农村地区老年人代谢及认知功能调查
发布时间：2018-10-11 11:50
【摘要】：目的 通过对天津市蓟县农村地区1268名60岁及以上的老年人认知功能的调查,研究家族史、个人史、及身高、体重、腰围(WC)、血压、心率等一般情况,及空腹血糖、甘油三酯(TG)、胆固醇(TC)等因素与认知功能障碍之间的关系,探讨天津农村地区老年人认知功能的特征,为提高农村地区认知功能障碍的知晓率和诊断率、治疗率提供依据。 方法 采用筛查法进行调查,收集性别、年龄、教育程度、个人高血压及冠心病史、饮酒、饮茶史等基本信息；测量身高、体重、WC、血压、心率；测定甘油三酯、胆固醇、空腹血糖水平；并行简易智能状态检查量表(mini-mental state examination,MMSE)评估认知功能,以MMSE分数文盲组17分,小学组22分,初中及以上组26分标准考虑认知功能受损,将调查人群分为MMSE分数正常组(700人),MMSE分数异常组(568人),比较两组年龄、性别、受教育年限、身高、体重、体重指数、WC、血压、心率、血糖、甘油三酯、胆固醇、及家族史和饮酒等生活习惯的差异。将调查对象按WC、体重指数、血压、血糖、胆固醇、甘油三酯数值正常与否进行分类,探讨代谢因素对认知状况的影响。将调查对象按不同年龄段分组,探讨年龄对于认知能力的影响。进行MMSE各亚项分析,探讨农村地区人群认知各亚项损害范围及损害程度。 结果 MMSE正常组较MMSE异常组男性比例高、WC长、舒张压高,差异有明显统计学意义(P0.05),MMSE正常组较MMSE异常组年龄轻、受教育年限高、有吸烟史比例高,差异有统计学意义(P0.01)。收缩压低、舒张压高、空腹血糖及胆固醇水平正常人群的MMSE分数较高,差异有统计学意义(P0.05)。WC、舒张压与MMSE分数呈显著正相关；收缩压、心率、空腹血糖、胆固醇与MMSE分数呈负相关(P0.05)。MMSE分数随年龄组升高呈下降趋势,年龄组越高人群MMSE分数低于正常值比例越大。全体调查对象的MMSE亚项评分均显著低于相应亚项总分(P0.01),其中亚项评分低于亚项总分例数最多的三项是：记忆力(91.64%)、注意力和计算力(74.84%)、定向力(70.27%)。较亚项总分下降幅度最大的三项是：记忆力(73.3%)、阅读能力(53%)、书写(47%)、结构能力(47%)。 结论 农村地区老年人认知状态与性别、年龄、教育年限、吸烟史、WC等相关；同时,体重、空腹血糖、胆固醇等代谢异常也与认知能力受损程度密切相关。农村地区老年人认知能力损害较广泛,其中记忆力、注意力和计算力、阅读、书写能力等认知能力亚项损害尤为严重。MMSE量表部分亚项测试方式适用于农村地区尚需调整。农村地区老年人认知状态不容乐观,农村地区老年人对于阿尔茨海默病(AD)的认识不足,农村地区老年人的认知状态需要得到更多关注。
[Abstract]:Objective to study the family history, personal history, height, weight, waist circumference, (WC), blood pressure, heart rate and fasting blood glucose in 1268 elderly people aged 60 years or over in Jixian rural area of Tianjin, and to study the family history, personal history, height, weight, waist circumference, blood pressure, heart rate and so on. The relationship between triglyceride (TG), cholesterol (TC) and cognitive dysfunction was studied. The characteristics of cognitive function of the elderly in rural areas of Tianjin were studied in order to provide evidence for improving the rate of awareness, diagnosis and treatment of cognitive dysfunction in rural areas. Methods basic information such as sex, age, education, history of hypertension and coronary heart disease, drinking and drinking tea were collected, height, weight, WC, blood pressure, heart rate, triglyceride were measured. Cholesterol, fasting blood glucose level, cognitive function were assessed with the simple Mental State Checklist (mini-mental state examination,MMSE). Cognitive impairment was assessed by MMSE scores of 17 in illiterate group, 22 in primary school group, and 26 in junior high school and above group. The subjects were divided into normal MMSE score group (700 patients with abnormal), MMSE score). Age, sex, years of education, height, body mass index, WC, blood pressure, heart rate, blood glucose, triglyceride, cholesterol were compared between the two groups. And differences in family history and drinking habits. The subjects were classified according to WC, body mass index, blood pressure, blood glucose, cholesterol and triglyceride values, and the effects of metabolic factors on cognitive status were investigated. The subjects were divided into different age groups to explore the effect of age on cognitive ability. The subitems of MMSE were analyzed to explore the extent and extent of cognitive impairment in rural population. Results the proportion of male, WC and diastolic blood pressure in MMSE normal group were higher than those in MMSE abnormal group, and the difference was statistically significant (P0.05). (P0.05), MMSE normal group was younger than that of MMSE abnormal group, higher education years and higher proportion of smoking history (P0.01). Systolic blood pressure was low, diastolic blood pressure was high, fasting blood glucose and cholesterol levels were higher, the difference was statistically significant (P0.05). WC, diastolic blood pressure and MMSE score were significantly positive correlation, systolic blood pressure, heart rate, fasting blood glucose, There was a negative correlation between cholesterol and MMSE score (P0.05). MMSE score increased with the increase of age group showed a downward trend, the higher the age group, the higher the MMSE score lower than the normal value of the proportion of the larger. The scores of MMSE subitems in all subjects were significantly lower than the total scores of corresponding subitems (P0.01). Among them, memory (91.64%), attention and numeracy (74.84%), and orientation (70.27%) were the most common subitems. Memory (73.3%), reading ability (53%), writing (47%), and structural ability (47%) were the three items with the largest decrease. Conclusion Cognitive status of the elderly in rural areas is related to gender, age, years of education, smoking history, WC, and metabolic abnormalities such as body weight, fasting blood glucose and cholesterol are also closely related to the degree of cognitive impairment. The cognitive impairment of the elderly in rural areas is more extensive, including memory, attention and calculation ability, reading ability, writing ability and so on. Some subitems of MMSE scale should be adjusted in rural areas. The cognitive state of the elderly in rural areas is not optimistic, and the cognition state of the elderly in rural areas is not enough to understand Alzheimer's disease (AD), and the cognitive state of the elderly in rural areas needs to be paid more attention.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16
本文编号：2264082
[Abstract]:Objective to study the family history, personal history, height, weight, waist circumference, (WC), blood pressure, heart rate and fasting blood glucose in 1268 elderly people aged 60 years or over in Jixian rural area of Tianjin, and to study the family history, personal history, height, weight, waist circumference, blood pressure, heart rate and so on. The relationship between triglyceride (TG), cholesterol (TC) and cognitive dysfunction was studied. The characteristics of cognitive function of the elderly in rural areas of Tianjin were studied in order to provide evidence for improving the rate of awareness, diagnosis and treatment of cognitive dysfunction in rural areas. Methods basic information such as sex, age, education, history of hypertension and coronary heart disease, drinking and drinking tea were collected, height, weight, WC, blood pressure, heart rate, triglyceride were measured. Cholesterol, fasting blood glucose level, cognitive function were assessed with the simple Mental State Checklist (mini-mental state examination,MMSE). Cognitive impairment was assessed by MMSE scores of 17 in illiterate group, 22 in primary school group, and 26 in junior high school and above group. The subjects were divided into normal MMSE score group (700 patients with abnormal), MMSE score). Age, sex, years of education, height, body mass index, WC, blood pressure, heart rate, blood glucose, triglyceride, cholesterol were compared between the two groups. And differences in family history and drinking habits. The subjects were classified according to WC, body mass index, blood pressure, blood glucose, cholesterol and triglyceride values, and the effects of metabolic factors on cognitive status were investigated. The subjects were divided into different age groups to explore the effect of age on cognitive ability. The subitems of MMSE were analyzed to explore the extent and extent of cognitive impairment in rural population. Results the proportion of male, WC and diastolic blood pressure in MMSE normal group were higher than those in MMSE abnormal group, and the difference was statistically significant (P0.05). (P0.05), MMSE normal group was younger than that of MMSE abnormal group, higher education years and higher proportion of smoking history (P0.01). Systolic blood pressure was low, diastolic blood pressure was high, fasting blood glucose and cholesterol levels were higher, the difference was statistically significant (P0.05). WC, diastolic blood pressure and MMSE score were significantly positive correlation, systolic blood pressure, heart rate, fasting blood glucose, There was a negative correlation between cholesterol and MMSE score (P0.05). MMSE score increased with the increase of age group showed a downward trend, the higher the age group, the higher the MMSE score lower than the normal value of the proportion of the larger. The scores of MMSE subitems in all subjects were significantly lower than the total scores of corresponding subitems (P0.01). Among them, memory (91.64%), attention and numeracy (74.84%), and orientation (70.27%) were the most common subitems. Memory (73.3%), reading ability (53%), writing (47%), and structural ability (47%) were the three items with the largest decrease. Conclusion Cognitive status of the elderly in rural areas is related to gender, age, years of education, smoking history, WC, and metabolic abnormalities such as body weight, fasting blood glucose and cholesterol are also closely related to the degree of cognitive impairment. The cognitive impairment of the elderly in rural areas is more extensive, including memory, attention and calculation ability, reading ability, writing ability and so on. Some subitems of MMSE scale should be adjusted in rural areas. The cognitive state of the elderly in rural areas is not optimistic, and the cognition state of the elderly in rural areas is not enough to understand Alzheimer's disease (AD), and the cognitive state of the elderly in rural areas needs to be paid more attention.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16
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