艾司西酞普兰与文拉法辛对抑郁症患者社会功能影响的比较

发布时间：2018-10-16 11:08

【摘要】：目的比较艾司西酞普兰与文拉法辛对抑郁症患者社会功能的影响。方法将符合抑郁症诊断标准的100例患者随机分为两组,分别给予艾司西酞普兰和文拉法辛进行治疗,采用汉密尔顿抑郁量表(HAMD-17)评价疗效,席汉残疾量表(SDS)和健康状况调查问卷(SF-36)评价患者社会功能改善情况,不良反应量表(TESS)评定不良反应严重程度。结果两组间不同时间HAMD评分无统计学差异(P0.05),但是均低于治疗前(P0.01)。治疗8周末,两组间有效率和治愈率比较差异无统计学意义(P0.05)。两组SDS总分、SF-36社会功能因子分8周末与基线比较差异均有统计学意义(P0.01),两组间SDS总分、SF-36社会功能因子分在治疗前及治疗8周末比较差异均无统计学意义(P0.05)。结论艾司西酞普兰与文拉法辛均能较好地改善抑郁症患者的社会功能,且差异无统计学意义。
[Abstract]:Objective to compare the effects of Escitalopram and venlafaxine on social function in patients with depression. Methods 100 patients with depression were randomly divided into two groups. They were treated with estalopram and venlafaxine respectively. Hamilton Depression scale (HAMD-17) was used to evaluate the efficacy. Shihan Disability scale (SDS) and Health status questionnaire (SF-36) were used to evaluate the improvement of social function and the severity of adverse reaction was evaluated by (TESS). Results there was no significant difference in HAMD score between the two groups at different time (P0.05), but it was lower than that before treatment (P0.01). After 8 weeks of treatment, there was no significant difference in the effective rate and cure rate between the two groups (P0.05). The total score of SDS, the score of social function factor of SF-36 at the end of 8 weeks were significantly higher than that of baseline (P0.01). The total score of SDS and the score of social function factor of SF-36 were not significantly different between the two groups before treatment and at the end of 8 weeks (P0.05). Conclusion both Escitalopram and venlafaxine can improve the social function of patients with depression.
【作者单位】：山东大学医学院;山东大学附属省立医院临床心理科;
【分类号】：R749.4

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