miR-137基因多态性与中国南方人群精神分裂症的关联性研究

发布时间：2018-10-16 15:24

【摘要】：目的采用中国南方汉族人群样本对miR-137基因多态性与精神分裂症的相关性进行研究。方法收集944例精神分裂症患者(精神分裂症组)及938例健康对照者(对照组)外周血液,采用SnaPshot技术对rs1625579位点进行基因分型,比较该位点等位基因频率分布在精神分裂症组和对照组,以及在精神分裂症患者临床变量分组中的差异。结果在精神分裂症组和对照组中基因型分布差异有统计学意义(χ~2=4.426,P=0.035),等位基因分布差异有统计学意义(χ~2=4.813,P=0.028)。按性别分组后,女性精神分裂患者和对照组之间基因型分布差异有统计学意义(χ~2=3.928,P=0.047),等位基因分布差异有统计学意义(χ~2=3.957,P=0.047)。结论研究结果证实了miR-137基因多态性与精神分裂症的相关性,同时发现了miR-137在精神分裂症发病调控过程中的性别特异性。
[Abstract]:Objective to study the association between miR-137 gene polymorphism and schizophrenia in Chinese Han population. Methods Peripheral blood fluid was collected from 944 schizophrenic patients (schizophrenia group) and 938 healthy controls (control group). Rs1625579 loci were genotyped by SnaPshot technique. The allelic frequency of this locus was compared between schizophrenia group and control group, as well as in the clinical variable group of schizophrenic patients. Results there were significant differences in genotype distribution and allele distribution between schizophrenia group and control group (蠂 ~ 2 ~ 2 ~ (4.426) P ~ (0.035) and allele distribution (蠂 ~ (2) ~ (4.813) P ~ (0.028). There was significant difference in genotype distribution and allele distribution between female schizophrenic patients and control group (蠂 ~ 2 = 3.928) and allele distribution (蠂 ~ (2) 3.957 P ~ (0.047). Conclusion the results confirm the association between miR-137 gene polymorphism and schizophrenia, and the sex specificity of miR-137 in the pathogenesis of schizophrenia.
【作者单位】：广东医科大学附属医院精神心理科;广东医科大学附属医院神经内科;广东医科大学附属医院血液透析中心;
【基金】：国家自然科学基金资助项目(31171219)
【分类号】：R749.3

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