青少年抑郁症患者前额叶磁共振波谱与记忆功能的相关性

发布时间：2018-10-24 07:08

【摘要】：目的利用质子磁共振波谱(1 H-MRS)探讨青少年抑郁症患者前额叶白质和灰质的代谢改变及代谢物与记忆功能的相关性。方法 24例首发青少年抑郁症患者和23例健康青少年被检测,采用多体素1 H-MRS技术获得双侧背外侧前额叶白质和双侧扣带回灰质的代谢水平,包括:N-乙酰天门冬氨酸盐(NAA)、胆碱复合物(Cho)、肌酸(Cr),利用韦氏记忆量表(WMS)测量其记忆功能。结果与对照组相比,抑郁组左背外侧前额叶白质NAA/Cr、Cho/Cr显著减低(P0.05),右背外侧前额叶白质NAA/Cr减低(P0.01),双侧前扣带回灰质的代谢物无明显差异;抑郁组记忆商数(MQ)较对照组明显降低(P0.01);抑郁组背外侧前额叶白质NAA/Cr与记忆商数呈正相关(P0.01)。结论前额叶白质的代谢异常参与青少年抑郁症的发生过程,双侧前额叶白质NAA/Cr降低可能与记忆障碍的神经病理学有关。
[Abstract]:Objective to investigate the metabolic changes of white matter and gray matter in prefrontal lobe and the correlation between metabolites and memory function in patients with adolescent depression by proton magnetic resonance spectroscopy (H-MRS). Methods Twenty-four first-episode adolescent depression patients and 23 healthy adolescents were detected and the metabolic levels of bilateral dorsolateral prefrontal white matter and bilateral cingulate gyrus gray matter were obtained by using multibody-1 H-MRS technique. N- acetyl aspartate (NAA), complex (Cho), creatine (Cr), was used to measure its memory function by Wechsler memory scale (WMS). Results compared with the control group, NAA/Cr,Cho/Cr in the left dorsolateral prefrontal lobe decreased significantly in the depression group (P0.05), and NAA/Cr in the right dorsolateral prefrontal lobe decreased (P0.01). There was no significant difference in the metabolites of the gray matter in the bilateral anterior cingulate gyrus. Memory quotient (MQ) in depression group was significantly lower than that in control group (P0.01), and NAA/Cr in dorsolateral prefrontal lobe was positively correlated with memory quotient (P0.01). Conclusion the abnormal metabolism of prefrontal white matter is involved in the process of adolescent depression. The decrease of NAA/Cr in bilateral prefrontal white matter may be related to the neuropathology of memory impairment.
【作者单位】：滨州医学院附属医院放射科;
【基金】：国家自然科学基金资助项目(No.81171303)~~
【分类号】：R749.4;R445.2

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