精神分裂症患者攻击行为的结构磁共振研究

发布时间：2018-10-24 07:42

【摘要】：目的运用结构磁共振方法研究伴有攻击行为的精神分裂症(schizophrenia,SZ)患者脑灰质结构特点,并探索其攻击行为与脑灰质结构的关系。方法收集伴有攻击行为的精神分裂症患者18例(SZ1组),以及性别、年龄与之相匹配的不伴有攻击行为精神分裂症患者18例(SZ2组)和正常对照18名。采用Buss和Perry攻击问卷(BussPerry aggression questionnaire,BP)中文版评估患者的攻击行为,采用3.0 T磁共振对被试进行脑结构扫描,应用基于体素的形态学测量方法对影像数据进行分析处理。结果与对照组相比,精神分裂症患者脑灰质体积改变的区域主要位于双侧的额叶、颞叶和枕叶(P0.05,Alpha Sim校正);与SZ2组相比,SZ1组灰质体积增加的脑区主要位于右侧的缘上回、中央后回、双侧的岛叶、眶额回(P0.05,Alpha Sim校正)。精神分裂症患者的BP评分与其右侧岛叶、中央后回、缘上回等脑区的灰质体积呈正关联(P0.01,Alpha Sim校正)。结论精神分裂症患者的攻击行为与脑灰质体积改变存在关联,中央后回、岛叶和缘上回等脑区可能参与精神分裂症患者攻击行为的神经机制。
[Abstract]:Objective to study the structural characteristics of gray matter in patients with aggressive schizophrenia (schizophrenia,SZ) by structural magnetic resonance (Mr), and to explore the relationship between aggressive behavior and gray matter structure. Methods 18 schizophrenic patients with aggressive behavior (SZ1 group), 18 patients with schizophrenia without aggressive behavior (SZ2 group) and 18 normal controls (gender and age matched) were collected. The Chinese version of Buss and Perry attack questionnaire (BussPerry aggression questionnaire,BP) was used to evaluate the aggressive behavior of the patients. The brain structure was scanned by 3.0T MRI and the image data were analyzed and processed by morphometry based on voxel. Results compared with the control group, the areas of gray matter volume changes in schizophrenic patients were mainly located in bilateral frontal lobe, temporal lobe and occipital lobe (P0.05 Alpha Sim correction), and the increased gray matter volume in SZ1 group was mainly located in the superior marginal gyrus of the right side compared with SZ2 group. Posterior central gyrus, bilateral insular lobe, orbital frontal gyrus (P0.05 Sim correction). The BP score was positively correlated with the gray matter volume in the right insular lobe, posterior central gyrus and superior marginal gyrus (P0.01 Alpha Sim correction). Conclusion the aggressive behavior of schizophrenic patients is associated with the change of gray matter volume. The posterior central gyrus, the insular lobe and the superior marginal gyrus may be involved in the neuromechanism of aggressive behavior in schizophrenic patients.
【作者单位】：南京医科大学附属无锡市精神卫生中心精神科;安徽医科大学医学心理学系;
【基金】：国家自然科学基金(编号:81301148) 无锡市医院管理中心联合攻关项目课题(编号:YGZXL1307) 江苏省自然科学基金(编号:BK2012545)
【分类号】：R749.3

【相似文献】