首发未用药抑郁症患者脑部白质纤维连接的弥散张量磁共振研究
发布时间：2018-10-26 07:23
【摘要】：背景：抑郁症是一种常见的情感性精神疾病，具有高发病率，高复发率，高致残率，高致死率、低治愈率的特点，严重的危害了人类的身心健康，极大地增加了社会的经济负担。目前，针对抑郁症的研究涉及众多的学科，但是没有得到统一的结论。目的:运用磁共振弥散张量成像技术，利用基于纤维束示踪的空间统计（tract-based spatialstatistics，TBSS）分析方法分析首发未用药青年重性抑郁症患者的弥散张量成像（diffusion tensor imaging，DTI）数据，探讨首发未用药青年抑郁症患者的脑白质微结构和纤维连接异常，探讨抑郁症可能的发病机制。方法:纳入32例（11男，21女）符合DSM-IV重性抑郁障碍诊断标准的重性抑郁患者和55例年龄、性别相匹配的健康人，进行17项汉密尔顿抑郁量表(17-items of Hamilton Depression Scale，HAMD-17)和贝克抑郁自评量表（Beck Depression Inventory，BDI）评定。要求抑郁组患者HAMD-17评分＞18分， BDI＞8分；对照组HAMD-17评分＜8分，BDI评分≤4分。对两组研究对象进行DTI扫描，采用TBSS分析法，比较抑郁患者和健康对照组的脑白质和纤维连接的各向异性分数（fractional anisotropy，FA值）。结果:抑郁组的大脑左右中央前回，右侧枕上回，右侧额上回和右侧岛叶的白质FA值低于正常对照组，（P＜0.05，体素大于50）；与之相对应左右上纵束、右侧下额枕束、右侧钩束和左右皮质脊髓束的FA值低于对照组。结论：1、首发未用药青年抑郁症患者的额叶，颞叶，枕叶存在白质损害。2、首发未用药抑郁患者的左右侧上纵束，右侧下额枕束，，左右皮质脊髓束、右侧钩束的纤维连接存在损害。3、抑郁症患者的脑白质微结构和纤维连接异常在抑郁症早期已经出现。4、内侧前额叶皮质—纹状体—苍白球—丘脑（medial prefrontal cortico-striato-pallido-thalamic，MPCSPT）神经环路异常可能是导致抑郁症发病的原因之一。
[Abstract]:Background: depression is a common affective mental disease, with high incidence, high recurrence rate, high disability rate, high mortality, low cure rate, serious harm to human physical and mental health. It has greatly increased the social economic burden. At present, the research on depression involves many subjects, but there is no uniform conclusion. Objective: to analyze the diffusion-weighted Zhang Liang imaging (diffusion tensor imaging,DTI) data of young patients with major depression without medication by using spatial statistics (tract-based spatialstatistics,TBSS) based on fiber tracer. To investigate the microstructures and fibrous connections of white matter in patients with first-episode untreated depression, and to explore the possible pathogenesis of depression. Methods: a total of 32 patients (11 men, 21 women) with severe depression who met the diagnostic criteria of DSM-IV and 55 healthy persons with age and sex matching were enrolled and 17 items of Hamilton Depression scale (17-items of Hamilton Depression Scale,) were administered. HAMD-17 and (Beck Depression Inventory,BDI). HAMD-17 score > 18, BDI > 8 in depression group, HAMD-17 < 8 and BDI 鈮
本文编号：2294993
[Abstract]:Background: depression is a common affective mental disease, with high incidence, high recurrence rate, high disability rate, high mortality, low cure rate, serious harm to human physical and mental health. It has greatly increased the social economic burden. At present, the research on depression involves many subjects, but there is no uniform conclusion. Objective: to analyze the diffusion-weighted Zhang Liang imaging (diffusion tensor imaging,DTI) data of young patients with major depression without medication by using spatial statistics (tract-based spatialstatistics,TBSS) based on fiber tracer. To investigate the microstructures and fibrous connections of white matter in patients with first-episode untreated depression, and to explore the possible pathogenesis of depression. Methods: a total of 32 patients (11 men, 21 women) with severe depression who met the diagnostic criteria of DSM-IV and 55 healthy persons with age and sex matching were enrolled and 17 items of Hamilton Depression scale (17-items of Hamilton Depression Scale,) were administered. HAMD-17 and (Beck Depression Inventory,BDI). HAMD-17 score > 18, BDI > 8 in depression group, HAMD-17 < 8 and BDI 鈮
本文编号：2294993
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