首发家族性和散发性精神分裂症患者认知功能的对照研究

发布时间：2018-10-31 07:42

【摘要】：目的探讨首发家族性与散发性精神分裂症患者的认知功能差异。方法纳入首发精神分裂症患者127例,其中家族性患者40例,散发性患者87例;同时纳入96名正常对照。采用修订的韦氏成人智力测验中部分量表对所有受试者进行认知功能评估,阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评定患者症状的严重程度,并分析认知功能与精神症状的相关性。结果家族性组与散发性组患者PANSS总分[(91.51±14.07)vs.(87.23±16.37)]、阳性症状分[(25.89±6.70)vs.(23.72±6.04)]、阴性症状分[(18.19±6.43)vs.(19.07±8.01)]差异无统计学意义(P0.05);两患者组全智商量表分、言语智商量表分和操作智商量表分均低于对照组(均P0.05),散发性组操作智商量表分低于家族性组(P0.05)。散发性组患者操作智商与PANSS总分(r=-0.46,P㩳0.01)、阳性症状分(r=-0.41,P=0.01)及阴性症状分(r=-0.36,P=0.02)呈负相关;木块图形校正分与PANSS总分(r=-0.41,P=0.01)及阳性症状分(r=-0.54,P0.01)呈负相关。而家族性组中无此相关关系(均P0.05)。结论首发精神分裂患者在发病初期认知功能即存在显著损害,散发性患者在智力方面受损较重,其受损程度与临床症状严重程度相关,而家族性患者智力的损害则独立于临床症状。
[Abstract]:Objective to explore the difference of cognitive function between first episode familial schizophrenia and sporadic schizophrenia. Methods 127 patients with first-episode schizophrenia were included, including 40 familial patients and 87 sporadic patients, and 96 normal controls. All subjects were assessed with the revised Wechsler Adult Intelligence Test (Wechsler Adult Intelligence Test) for cognitive function, positive and negative symptom scale (positive and negative syndrome scale,PANSS) to assess the severity of symptoms. The correlation between cognitive function and mental symptoms was analyzed. Results the total PANSS score of familial group and sporadic group [(91.51 卤14.07) vs. (87.23 卤16.37)], the positive symptom score [(25.89 卤6.70) vs. () 23.72 卤6.04], The negative symptom score [(18.19 卤6.43) vs. (19.07 卤8.01)] had no significant difference (P0.05). The scores of total IQ, verbal intelligence quotient and operational intelligence quotient in the two groups were lower than those in the control group (P0.05), and the scores in sporadic group were lower than those in familial group (P0.05). In sporadic group, the scores of PANSS, positive symptoms and negative symptoms were negatively correlated with the total score of PANSS (r-0.46), the score of positive symptom (r-0.41) and the score of negative symptom (r-0.36% P0. 02). The score of block figure correction was negatively correlated with the total score of PANSS (r-0.41) and the score of positive symptoms (r-0.54% P0.01). There was no correlation in familial group (P0.05). Conclusion the cognitive function of the first episode schizophrenic patients was significantly impaired in the early stage of onset, and the sporadic patients had severe mental impairment, and the degree of the damage was related to the severity of clinical symptoms. Mental impairment in familial patients is independent of clinical symptoms.
【作者单位】：四川大学华西心理卫生中心;
【基金】：国家自然科学基金面上项目(编号:30670757) “十一五”国家科技支撑计划(编号:2007BAI17B04) 博士点新教师基金(编号:20110181120033)
【分类号】：R749.3

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