注射用鼠神经生长因子治疗老年痴呆患者的临床研究

发布时间：2018-11-03 13:20

【摘要】：目的观察注射用鼠神经生长因子对老年痴呆的疗效及血清细胞因子的影响。方法 90例老年痴呆患者随机分为试验组45例和对照组45例。对照组给予常规治疗,试验组在常规治疗的基础上静脉滴注注射用鼠神经生长因子20μg,每天1次,连续治疗6周。分别于治疗前、治疗后6,12周评定2组患者认知功能、痴呆程度、日常生活自理能力,并用酶联免疫吸附试验检测血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平。结果治疗12周后,2组简易智力状况检查法(MMSE)、日常活动能力(ADL)、临床痴呆评定量表(CDR)差异有统计学意义(P0.05)。试验组治疗后6,12周的血清IL-1β分别为(20.88±5.83),(18.35±3.96)ng·L~(-1),IL-6为(24.33±8.56),(18.85±5.83)ng·L~(-1),CRP分别为(6.43±1.65),(5.27±0.63)ng·L~(-1),TNF-α分别为(40.52±8.33),(36.34±5.92)ng·L~(-1);对照组IL-1β分别为(21.12±6.12),(20.76±4.83)ng·L~(-1),IL-6为(24.84±9.13),(21.64±6.68)ng·L~(-1),CRP为(6.73±1.73),(6.17±0.95)ng·L~(-1),TNF-α为(40.85±9.15),(39.46±6.44)ng·L~(-1)。治疗12周后,2组IL-1β、IL-6、CRP、TNF-α差异有统计学意义(P0.05)。对照组出现轻度头疼1例,药物不良反应发生率为0.02%(1/45例),试验组未发生药物不良反应。结论注射用鼠神经生长因子对老年痴呆患者临床疗效显著,可改善患者生活能力,舒缓痴呆症状,降低机体血清细胞因子水平。
[Abstract]:Objective to observe the effect of nerve growth factor (NGF) on senile dementia and the effect of serum cytokines. Methods 90 senile dementia patients were randomly divided into trial group (n = 45) and control group (n = 45). The control group was treated with routine therapy, and the experimental group was treated with 20 渭 g NGF once a day for 6 weeks on the basis of routine treatment. Cognitive function, dementia degree, self-care ability of daily living were assessed before and 6 weeks after treatment. Serum interleukin-1 尾 (IL-1 尾) and interleukin-6 (IL-6) were detected by Elisa. C-reactive protein (CRP), tumor necrosis factor-伪 (TNF- 伪) level. Results after 12 weeks of treatment, there was a statistically significant difference in (CDR) between the two groups (P0.05) by (MMSE), daily activity (ADL), clinical dementia rating scale (P 0.05). The serum IL-1 尾 was (20.88 卤5.83), (18.35 卤3.96) ng L ~ (-1) and IL-6 was (24.33 卤8.56), (18.85 卤5.83) ng L ~ (-1) in the experimental group at 12 weeks after treatment. CRP was (6.43 卤1.65), (5.27 卤0.63) ng L ~ (-1), TNF- 伪 was (40.52 卤8.33), () 36.34 卤5.92 ng L ~ (-1); In control group, IL-1 尾 was (21.12 卤6.12), (20.76 卤4.83) ng L ~ (-1), IL-6 was (24.84 卤9.13), (21.64 卤6.68) ng L ~ (-1), CRP was (6.73 卤1.73). (6.17 卤0.95) ng L ~ (-1), TNF- 伪 was (40.85 卤9.15), () 39.46 卤6.44 ng L ~ (-1). After 12 weeks of treatment, there were significant differences in IL-1 尾 and IL-6,CRP,TNF- 伪 between the two groups (P0.05). The incidence of adverse drug reactions in the control group was 0.02% (1 / 45 cases), but no adverse drug reaction was found in the trial group. Conclusion the effect of nerve growth factor for injection on senile dementia patients is significant. It can improve the patients' living ability, relieve the symptoms of dementia and reduce the level of serum cytokines.
【作者单位】：恩施土家族苗族自治州民族医院脑病科;恩施土家族苗族自治州民族医院妇产科;湖北省中医院肝胆外科;
【分类号】：R977.6

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