原络通经针法配合药物治疗非痴呆血管性认知障碍的临床研究

发布时间：2018-11-10 23:58

【摘要】：目的：探讨原络通经针法配合药物(多奈哌齐片)治疗非痴呆血管性认知障碍的临床疗效及其对事件相关电位P300的影响。方法：将40例符合纳入、排除标准的非痴呆血管性认知障碍患者随机分为治疗组和对照组,每组20例。治疗组采用原络通经针法配合药物(多奈哌齐片)治疗,对照组采用单纯药物(多奈哌齐片)治疗。两组疗效均为6周。采用肌电-诱发电位仪听觉odball程序由同一操作者对患者治疗前后各检查1次；由专业人员于治疗前后对患者进行简易精神状态检查量表(MMSE)评分和蒙特利尔认知评估量表(MoCA)评分评定,并进行治疗前后MMSE和MoCA评分及事件相关电位P300的N2和P3潜伏期、波幅变化比较。结果：治疗组总有效率为85.00%,对照组总有效率为65.00%,两组总有效率比较差异具有统计学意义(p0.05)。两组治疗后简易精神状态检查量表(MMSE)评分和蒙特利尔认知评估量表(MoCA)评分均较同组治疗前有明显提高(p0.01,p0.05)；治疗组治疗后简易精神状态检查量表(MMSE)评分和蒙特利尔认知评估量表(MoCA)评分均优于对照组,两组比较差异具有统计学意义(p0.05)。两组患者治疗后N2和P3潜伏期与治疗前比较均明显缩短组内治疗前后潜伏期比较,差异均有统计学意义(p0.01,p0.05)；两组患者治疗后N2和P3波幅与治疗前比较均明显增高,组内治疗前后波幅比较,差异均有统计学意义(p0.01,p0.05)。治疗后,治疗组N2和P3潜伏期缩短及波幅增高均显著优于对照组,两组比较差异均有统计学意义(p0.05)。结论：原络通经针法联合药物(多奈哌齐片)可用于非痴呆血管性认知障碍的治疗,能够改善患者的认知功能,是非痴呆血管性认知障碍的有效干预方法。
[Abstract]:Objective: to investigate the clinical effect of Fuluo Tongjing acupuncture combined with medicine (Donepezil tablet) in the treatment of non-dementia vascular cognitive impairment and its effect on event-related potential (P300). Methods: 40 patients with non-dementia vascular cognitive impairment were randomly divided into treatment group and control group with 20 cases in each group. The treatment group was treated with original collaterals and meridian acupuncture combined with medicine (Donepezil tablet), while the control group was treated with simple drug (Donepezil tablet). The curative effect was 6 weeks in both groups. The electromyoelectric evoked potentiometer auditory odball program was used to examine the patients before and after treatment. Before and after treatment, the patients were assessed with the mini-mental state examination scale (MMSE) and the Montreal Cognitive Assessment scale (MoCA). The MMSE and MoCA scores and the N2 and P3 latencies of event-related potentials (P300) were evaluated before and after treatment. Comparison of amplitude variations. Results: the total effective rate was 85.00 in the treatment group and 65.00 in the control group. The difference of the total effective rate between the two groups was statistically significant (p0.05). The scores of (MMSE) and (MoCA) were significantly higher in the two groups after treatment than those before treatment (p0.01 / p0.05). The (MMSE) score of mini-mental state examination scale and the (MoCA) score of Montreal Cognitive Assessment scale in the treatment group were better than those in the control group after treatment. The difference between the two groups was statistically significant (p0.05). The latencies of N2 and P3 in the two groups were significantly shortened after treatment compared with those before and after treatment, and the differences were statistically significant (p0.01 / p0.05). The amplitude of N2 and P3 was significantly increased after treatment in both groups, and the difference was statistically significant before and after treatment (p0.01 / p0.05). After treatment, the latency and amplitude of N2 and P3 in the treatment group were significantly shorter than those in the control group, and the difference between the two groups was statistically significant (p0.05). Conclusion: Yuanluotong meridian acupuncture combined with medicine (Donepezil tablet) can be used in the treatment of non-dementia vascular cognitive disorders, can improve the cognitive function of patients, non-dementia vascular cognitive impairment of effective intervention.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1

【参考文献】